MicroRNA expression classification for human disease prediction

被引:1
作者
Slimene, Ines [1 ]
Messaoudi, Imen [1 ,2 ]
Elloumi, Afef [1 ,3 ]
Lachiri, Zied [1 ]
机构
[1] Univ Tunis El Manar, Natl Sch Engineers Tunis, Elect Engn Dept, SITI Lab, Tunis, Tunisia
[2] Univ Carthage, Higher Inst Informat Technol & Commun, Ind Comp Dept, Tunis, Tunisia
[3] Univ Carthage, Natl Sch Engineers Carthage, Elect Engn Dept, Tunis, Tunisia
来源
2021 18TH INTERNATIONAL MULTI-CONFERENCE ON SYSTEMS, SIGNALS & DEVICES (SSD) | 2021年
关键词
microRNA; disease; RPM; Classification; IDENTIFICATION;
D O I
10.1109/SSD52085.2021.9429451
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Recent research has shown that microRNA plays an important role in human disease specification. Study of miRNA expression helps to accelerate the diagnosis of diseases and to anticipate treatment. However experimental identification of diseases from microRNA expression such as RPM poses difficulties. Nowadays, we haven't enough bioinformatics algorithm to predict the association between miRNA and diseases. Herein, we present a machine learning based approach for distinguishing patient from normal person based on miRNA expression. In this paper, we compare different machine learning algorithms such as SVM, KNN and logistic regression to predict infected gene from miRNAs RPM values.
引用
收藏
页码:1209 / 1214
页数:6
相关论文
共 16 条
  • [1] Bedre R., 2017, Gene expression units explained: Rpm, rpkm, fpkm, tpm, deseq, tmm, scnorm, getmm, and combat-seq
  • [2] Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
    Cogswell, John P.
    Ward, James
    Taylor, Ian A.
    Waters, Michelle
    Shi, Yunling
    Cannon, Brian
    Kelnar, Kevin
    Kemppainen, Jon
    Brown, David
    Chen, Caifu
    Prinjha, Rab K.
    Richardson, Jill C.
    Saunders, Ann M.
    Roses, Allen D.
    Richards, Cynthia A.
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2008, 14 (01) : 27 - 41
  • [3] DiGangi EA, 2013, RESEARCH METHODS IN HUMAN SKELETAL BIOLOGY, P117
  • [4] Duda R. O., 1973, Pattern classification and scene analysis, V3
  • [5] Dudani S. A., 1976, IEEE Transactions on Systems, Man and Cybernetics, VSMC-6, P325, DOI 10.1109/TSMC.1976.5408784
  • [6] Predicting human microRNA-disease associations based on support vector machine
    Jiang, Qinghua
    Wang, Guohua
    Jin, Shuilin
    Li, Yu
    Wang, Yadong
    [J]. INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS, 2013, 8 (03) : 282 - 293
  • [7] Identification of active transcription factor and miRNA regulatory pathways in Alzheimer's disease
    Jiang, Wei
    Zhang, Yan
    Meng, Fanlin
    Lian, Baofeng
    Chen, Xiaowen
    Yu, Xuexin
    Dai, Enyu
    Wang, Shuyuan
    Liu, Xinyi
    Li, Xiang
    Wang, Lihong
    Li, Xia
    [J]. BIOINFORMATICS, 2013, 29 (20) : 2596 - 2602
  • [8] Lea MA, 2010, FUTURE ONCOL, V6, P993, DOI [10.2217/fon.10.53, 10.2217/FON.10.53]
  • [9] Malkauthekar M. D., 2013, ANAL EUCLIDEAN DISTA
  • [10] Patle A, 2013, 2013 INTERNATIONAL CONFERENCE ON ADVANCES IN TECHNOLOGY AND ENGINEERING (ICATE)