The Role of Sfp1 in Candida albicans Cell Wall Maintenance

被引：3
作者：
Chang, Che-Kang [1 ]
Yang, Min-Chi [1 ]
Chen, Hsueh-Fen [1 ]
Liao, Yi-Ling [1 ]
Lan, Chung-Yu [1 ,2 ,3 ]
机构：
[1] Natl Tsing Hua Univ, Inst Mol & Cellular Biol, Hsinchu 30013, Taiwan
[2] Natl Tsing Hua Univ, Dept Life Sci, Hsinchu 30013, Taiwan
[3] Natl Tsing Hua Univ, Sch Med, Hsinchu 30013, Taiwan
来源：
JOURNAL OF FUNGI | 2022年 / 8卷 / 11期
关键词：
Candida albicans; cell wall integrity; cell wall stress response; Sfp1; Cas5; SURFACE HYDROPHOBICITY; INTEGRITY; GENE; DISRUPTION; VIRULENCE; ADHESINS;
D O I：
10.3390/jof8111196
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The cell wall is the first interface for Candida albicans interaction with the surrounding environment and the host cells. Therefore, maintenance of cell wall integrity (CWI) is crucial for C. albicans survival and host-pathogen interaction. In response to environmental stresses, C. albicans undergoes cell wall remodeling controlled by multiple signaling pathways and transcription regulators. Here, we explored the role of the transcription factor Sfp1 in CWI. A deletion of the SFP1 gene not only caused changes in cell wall properties, cell wall composition and structure but also modulated expression of cell wall biosynthesis and remodeling genes. In addition, Cas5 is a known transcription regulator for C. albicans CWI and cell wall stress response. Interestingly, our results indicated that Sfp1 negatively controls the CAS5 gene expression by binding to its promoter element. Together, this study provides new insights into the regulation of C. albicans CWI and stress response.
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页数：14
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