The Role of Sfp1 in Candida albicans Cell Wall Maintenance

被引:3
|
作者
Chang, Che-Kang [1 ]
Yang, Min-Chi [1 ]
Chen, Hsueh-Fen [1 ]
Liao, Yi-Ling [1 ]
Lan, Chung-Yu [1 ,2 ,3 ]
机构
[1] Natl Tsing Hua Univ, Inst Mol & Cellular Biol, Hsinchu 30013, Taiwan
[2] Natl Tsing Hua Univ, Dept Life Sci, Hsinchu 30013, Taiwan
[3] Natl Tsing Hua Univ, Sch Med, Hsinchu 30013, Taiwan
关键词
Candida albicans; cell wall integrity; cell wall stress response; Sfp1; Cas5; SURFACE HYDROPHOBICITY; INTEGRITY; GENE; DISRUPTION; VIRULENCE; ADHESINS;
D O I
10.3390/jof8111196
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The cell wall is the first interface for Candida albicans interaction with the surrounding environment and the host cells. Therefore, maintenance of cell wall integrity (CWI) is crucial for C. albicans survival and host-pathogen interaction. In response to environmental stresses, C. albicans undergoes cell wall remodeling controlled by multiple signaling pathways and transcription regulators. Here, we explored the role of the transcription factor Sfp1 in CWI. A deletion of the SFP1 gene not only caused changes in cell wall properties, cell wall composition and structure but also modulated expression of cell wall biosynthesis and remodeling genes. In addition, Cas5 is a known transcription regulator for C. albicans CWI and cell wall stress response. Interestingly, our results indicated that Sfp1 negatively controls the CAS5 gene expression by binding to its promoter element. Together, this study provides new insights into the regulation of C. albicans CWI and stress response.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] Role of SFP1 in the Regulation of Candida albicans Biofilm Formation
    Chen, Hsueh-Fen
    Lan, Chung-Yu
    PLOS ONE, 2015, 10 (06):
  • [2] The Transcription Factor Sfp1 Regulates the Oxidative Stress Response in Candida albicans
    Lee, Shao-Yu
    Chen, Hsueh-Fen
    Yeh, Ying-Chieh
    Xue, Yao-Peng
    Lan, Chung-Yu
    MICROORGANISMS, 2019, 7 (05):
  • [3] Candida albicans Sfp1 Is Involved in the Cell Wall and Endoplasmic Reticulum Stress Responses Induced by Human Antimicrobial Peptide LL-37
    Hsu, Chun-Min
    Liao, Yi-Ling
    Chang, Che-Kang
    Lan, Chung-Yu
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (19)
  • [4] Signaling the glycoshield: Maintenance of the Candida albicans cell wall
    Ernst, Joachim F.
    Pla, Jesus
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2011, 301 (05) : 378 - 383
  • [5] Role of Pir1 in the construction of the Candida albicans cell wall
    Martínez, AI
    Castillo, L
    Garcerá, A
    Elorza, MV
    Valentín, E
    Sentandreu, R
    MICROBIOLOGY-SGM, 2004, 150 : 3151 - 3161
  • [6] The transcriptional activity of Sfp1 regulates cell growth and division
    Tomassetti, Susanna
    Gloor, Yvonne
    Bruzzone, Maria Jessica
    Kubik, Stefan
    Jacquet, Philippe
    Rougemont, Jacques
    Shore, David
    YEAST, 2015, 32 : S99 - S100
  • [7] Sfp1 plays a key role in yeast ribosome biogenesis
    Fingerman, I
    Nagaraj, V
    Norris, D
    Vershon, AK
    EUKARYOTIC CELL, 2003, 2 (05) : 1061 - 1068
  • [8] Sfp1 and Rtg3 reciprocally modulate carbon source-conditional stress adaptation in the pathogenic yeast Candida albicans
    Kastora, Stavroula L.
    Herrero-de-Dios, Carmen
    Avelar, Gabriela M.
    Munro, Carol A.
    Brown, Alistair J. P.
    MOLECULAR MICROBIOLOGY, 2017, 105 (04) : 620 - 636
  • [9] Cellular morphologies of cdc14, sfp1 and cdc14 sfp1 mutants
    Paliulis, LV
    Byrne, M
    Raymond, WE
    MOLECULAR BIOLOGY OF THE CELL, 1999, 10 : 130A - 130A
  • [10] Revisiting the role of yeast Sfp1 in ribosome biogenesis and cell size control: a chemostat study
    Cipollina, Chiara
    van den Brink, Joost
    Daran-Lapujade, Pascale
    Pronk, Jack T.
    Vai, Marina
    de Winde, Johannes H.
    MICROBIOLOGY-SGM, 2008, 154 : 337 - 346