Neuroprotective effect of electroacupuncture against acute ischemic stroke via PI3K-Akt-mTOR pathway-mediated autophagy

被引：18
作者：
Yovitania, Velika [1 ,2 ]
Fu, Qin-Hui [1 ]
Pei, Jian
Zhou, Hua [3 ,4 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Dept Acupuncture, Shanghai, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Fac Acupuncture Moxibust & Tuina, Shanghai, Peoples R China
[3] Macau Univ Sci & Technol, Fac Chinese Med, Ave Wailong, Taipa, Madhya Pradesh, Peoples R China
[4] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wailong, Taipa, Madhya Pradesh, Peoples R China
来源：
WORLD JOURNAL OF TRADITIONAL CHINESE MEDICINE | 2022年 / 8卷 / 03期
关键词：
Acupuncture; autophagy; ischemic stroke; nerve regeneration; neuroprotection; FOCAL CEREBRAL-ISCHEMIA; THERAPEUTIC TARGETS; REPERFUSION INJURY; SIGNALING PATHWAY; BRAIN-INJURY; ACUPUNCTURE; MECHANISMS; APOPTOSIS; RATS; INFLAMMATION;
D O I：
10.4103/2311-8571.333712
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Acupuncture has been used to treat ischemic stroke, and mounting evidence demonstrates the neuroprotective and autophagy-mediated actions of electroacupuncture (EA). This review summarizes the evidence that EA affects different stages of autophagy, its neuroprotective action, and effects of different acupoints in treating ischemic stroke. Systematic searches were conducted on English and Chinese databases (MEDLINE, Elsevier, ScienceDirect, Cochrane Library, and China National Knowledge Infrastructure). Studies published up until February 2021 were considered for inclusion, and a final of fifty articles were included in this review. There is evidence that acupuncture promotes neuroprotection by modulating autophagy, and the treatment effectiveness is related to the acupoint selection and timing of treatment administration.
引用
收藏
页码：339 / 349
页数：11
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