Ghrelin: a metabolic signal affecting the reproductive system

被引：52
作者：
Lorenzi, Teresa [1 ]
Meli, Rosaria [2 ]
Marzioni, Daniela [1 ]
Morroni, Manrico [1 ]
Baragli, Alessandra [3 ]
Castellucci, Mario [1 ]
Gualillo, Oreste [4 ]
Muccioli, Giampiero [3 ]
机构：
[1] Polytech Univ Marche, Dept Mol Pathol & Innovat Therapies, I-60020 Ancona, Italy
[2] Univ Naples Federico II, Fac Pharm, Dept Expt Pharmacol, I-80131 Naples, Italy
[3] Univ Turin, Dept Anat Pharmacol & Forens Med, Div Med Pharmacol, I-10125 Turin, Italy
[4] Univ Santiago, Clin Hosp, NeuroEndocrine Interact Rheumatol & Inflammatory, NEIRID Lab,Lab 9,IDIS Inst Invest Sanitaria Santi, Santiago De Compostela 15706, Spain
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 02期
关键词：
Ghrelin; Growth hormone; Energy homeostasis; Embryonic development; Reproduction; GROWTH-HORMONE SECRETAGOGUE; DES-ACYL GHRELIN; STEM-CELL FACTOR; OVARIECTOMIZED RHESUS-MONKEY; GH-RELEASING HORMONE; MESSENGER-RIBONUCLEIC-ACID; PANCREATIC BETA-CELLS; LUTEINIZING-HORMONE; FOOD-INTAKE; FEMALE RATS;
D O I：
10.1016/j.cytogfr.2009.02.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ghrelin, an acylated 28 amino acid gastric peptide, was isolated from the stomach as an endogenous ligand for growth hormone (GH) secretagogue receptor in 1999. Circulating ghrelin is mainly produced by specific cells in the stomach's oxyntic glands. Ghrelin potently stimulates GH release and food intake and exhibits diverse effects, including ones on glucose metabolism and on secretion and motility of the gastrointestinal tract. Besides these effects on food intake and energy homeostasis, ghrelin is also involved in controlling reproductive functions, and a role for it as a novel regulator of the hypothalamic-pituitary gonadal axis is clearly emerging. We review recent ghrelin research with emphasis on its roles in the reproductive axis. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：137 / 152
页数：16
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