Ghrelin: a metabolic signal affecting the reproductive system

被引：52
作者：
Lorenzi, Teresa [1 ]
Meli, Rosaria [2 ]
Marzioni, Daniela [1 ]
Morroni, Manrico [1 ]
Baragli, Alessandra [3 ]
Castellucci, Mario [1 ]
Gualillo, Oreste [4 ]
Muccioli, Giampiero [3 ]
机构：
[1] Polytech Univ Marche, Dept Mol Pathol & Innovat Therapies, I-60020 Ancona, Italy
[2] Univ Naples Federico II, Fac Pharm, Dept Expt Pharmacol, I-80131 Naples, Italy
[3] Univ Turin, Dept Anat Pharmacol & Forens Med, Div Med Pharmacol, I-10125 Turin, Italy
[4] Univ Santiago, Clin Hosp, NeuroEndocrine Interact Rheumatol & Inflammatory, NEIRID Lab,Lab 9,IDIS Inst Invest Sanitaria Santi, Santiago De Compostela 15706, Spain
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 02期
关键词：
Ghrelin; Growth hormone; Energy homeostasis; Embryonic development; Reproduction; GROWTH-HORMONE SECRETAGOGUE; DES-ACYL GHRELIN; STEM-CELL FACTOR; OVARIECTOMIZED RHESUS-MONKEY; GH-RELEASING HORMONE; MESSENGER-RIBONUCLEIC-ACID; PANCREATIC BETA-CELLS; LUTEINIZING-HORMONE; FOOD-INTAKE; FEMALE RATS;
D O I：
10.1016/j.cytogfr.2009.02.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ghrelin, an acylated 28 amino acid gastric peptide, was isolated from the stomach as an endogenous ligand for growth hormone (GH) secretagogue receptor in 1999. Circulating ghrelin is mainly produced by specific cells in the stomach's oxyntic glands. Ghrelin potently stimulates GH release and food intake and exhibits diverse effects, including ones on glucose metabolism and on secretion and motility of the gastrointestinal tract. Besides these effects on food intake and energy homeostasis, ghrelin is also involved in controlling reproductive functions, and a role for it as a novel regulator of the hypothalamic-pituitary gonadal axis is clearly emerging. We review recent ghrelin research with emphasis on its roles in the reproductive axis. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：137 / 152
页数：16
相关论文
共 50 条
  • [31] Ghrelinergic system in fish ovaries and ghrelin inhibition of germinal vesicle breakdown in zebrafish oocytes
    Shepperd, Erin
    Peng, Chun
    Unniappan, Suraj
    GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2012, 176 (03) : 426 - 431
  • [32] GHRELIN PHYSIOLOGY AND PATHOPHYSIOLOGY: FOCUS ON THE CARDIOVASCULAR SYSTEM
    Gruzdeva, O., V
    Borodkina, D. A.
    Belik, E., V
    Akbasheva, O. E.
    Palicheva, E., I
    Barbarash, O. L.
    KARDIOLOGIYA, 2019, 59 (03) : 60 - 67
  • [33] Ghrelin and the metabolic balance
    Ukkola, O
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2005, 28 (09) : 849 - 852
  • [34] The effect of intracerebroventricular infusions of ghrelin on the secretory activity of the GnRH/LH system in peripubertal ewes
    Wojcik-Gladysz, A.
    Wankowska, M.
    Gajewska, A.
    Misztal, T.
    Szlis, M.
    Polkowska, J.
    JOURNAL OF ANIMAL AND FEED SCIENCES, 2014, 23 (04): : 299 - 308
  • [35] The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary Symptoms of Alzheimer's Disease
    Kim, Sujin
    Nam, Yunkwon
    Shin, Soo Jung
    Park, Yong Ho
    Jeon, Seong Gak
    Kim, Jin-il
    Kim, Min-Jeong
    Moon, Minho
    FRONTIERS IN NEUROSCIENCE, 2020, 14
  • [36] Physiological significance of ghrelin revealed by studies using genetically engineered mouse models with modifications in the ghrelin system
    Ariyasu, Hiroyuki
    Akamizu, Takashi
    ENDOCRINE JOURNAL, 2015, 62 (11) : 953 - 963
  • [37] The potential for nanomaterial toxicity affecting the male reproductive system
    Li, Jiangxue
    Ning, Manman
    Zhang, Yiming
    Liu, Qianglin
    Liu, Kai
    Zhang, Hongjie
    Zhao, Yuliang
    Chen, Chunying
    Liu, Ying
    WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2022, 14 (06)
  • [38] Metabolic Status and Ghrelin Regulate Plasma Levels and Release of Ovarian Hormones in Layer Chicks
    Sirotkin, A. V.
    Harrath, A. H.
    Grossmann, R.
    PHYSIOLOGICAL RESEARCH, 2017, 66 (01) : 85 - 92
  • [39] Reproductive performance of male mice after hypothalamic ghrelin administration
    Belen Poretti, Maria
    Frautschi, Camila
    Luque, Eugenia
    Bianconi, Santiago
    Carolina Martini, Ana
    Stutz, Graciela
    Vincenti, Laura
    Emilia Santillan, Maria
    Ponzio, Marina
    Schioth, Helgi B.
    Fiol de Cuneo, Marta
    Paola Carlini, Valeria
    REPRODUCTION, 2018, 156 (02) : 121 - 132
  • [40] CROSS-TALK BETWEEN LEPTIN, GHRELIN AND OREXINS IN THE CENTRAL NERVOUS SYSTEM OF SEASONAL ANIMALS - A REVIEW
    Kirsz, Katarzyna
    Szczesna, Malgorzata
    Borsuk, Anna
    Zieba, Dorota A.
    ANNALS OF ANIMAL SCIENCE, 2017, 17 (02): : 337 - 350
12345