Anti-fatigue and vasoprotective effects of quercetin-3-O-gentiobiose on oxidative stress and vascular endothelial dysfunction induced by endurance swimming in rats

被引：64
作者：
Lin, Yin [1 ,2 ]
Liu, Hua-Liang [1 ]
Fang, Jie [3 ,4 ]
Yu, Chen-Huan [3 ]
Xiong, Yao-Kang [4 ]
Yuan, Ke [1 ]
机构：
[1] Zhejiang Agr & Forestry Univ, Nurturing Stn, State Key Lab Subtrop Silviculture, Linan 311300, Peoples R China
[2] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
[3] Zhejiang Acad Med Sci, Hangzhou 310013, Zhejiang, Peoples R China
[4] Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 68卷
关键词：
Flavonoid; Fatigue; Vascular endothelial dysfunction; Oxidative stress; Antioxidant; EPIGALLOCATECHIN GALLATE; REACTIVE OXYGEN; DNA-DAMAGE; ANTIOXIDANT; FLAVONOIDS; EXERCISE; EXTRACT; SUPPLEMENTATION; IDENTIFICATION; ACTIVATION;
D O I：
10.1016/j.fct.2014.03.026
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Chronic fatigue accumulation increases the incidence of cardiovascular disease while the treatment of antioxidants could prevent this development. We have previously shown that quercetin-3-O-gentiobiose (QC), a flavonoid isolated from tonic herb Okra, possesses anti-oxidative properties. In the present study, the protective effects of QG were evaluated in a rat model of load-induced endurance swimming. Oral administration of QG at the doses of 25-75 mg/kg could significantly improve the endurance capability of rats to fatigue along with decrease serum lactic acid and blood urea nitrogen levels were decreased. Moreover, QG could alleviate vascular impairments, enhance the activities of antioxidant enzymes and attenuate the levels of inflammatory cytokines (MCP-1, IL-6 and TNF-alpha). The results indicated that QG had anti-fatigue and vasoprotective effects and represented a potential agent for the treatment of aortic pathology involved with fatigue- and related syndrome. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：290 / 296
页数：7
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