Meningococcal carriage by age in the African meningitis belt: a systematic review and meta-analysis

被引:0
作者
Cooper, L., V [1 ]
Kristiansen, P. A. [2 ]
Christensen, H. [3 ]
Karachaliou, A. [1 ]
Trotter, C. L. [1 ]
机构
[1] Univ Cambridge, Dept Vet Med, Dis Dynam Unit, Madingiey Rd, Cambridge CB3 0ES, England
[2] Norwegian Inst Publ Hlth, WHO Collaborating Ctr Reference & Res Meningococc, Oslo, Norway
[3] Univ Bristol, Bristol Med Sch, Popuiat Hlth Sci, Oakfieid House, Bristol BS8 2BN, Avon, England
关键词
Infectious disease epidemiology; meningitis-bacterial; meningococcal disease; meta-analysis; pharyngeal carriage; BURKINA-FASO; NEISSERIA-MENINGITIDIS; SEROGROUP; IMMUNITY; VACCINATION; EPIDEMIC; INFECTION; DISEASE; IMPACT;
D O I
10.1017/S0950268819001134
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Meningococcal carriage dynamics drive patterns of invasive disease. The distribution of carriage by age has been well described in Europe, but not in the African meningitis belt, a region characterised by frequent epidemics of meningitis. We aimed to estimate the age-specific prevalence of meningococcal carriage by season in the African meningitis belt. We searched PubMed, Web of Science, the Cochrane Library and grey literature for papers reporting carriage of Neisseria meningitidis in defined age groups in the African meningitis belt. We used a mixed-effects logistic regression to model meningococcal carriage prevalence as a function of age, adjusting for season, location and year. Carriage prevalence increased from low prevalence in infants (0.595% in the rainy season, 95% CI 0.482-0.852%) to a broad peak at age 10 (1.94%, 95% CI 1.87-2.47%), then decreased in adolescence. The odds of carriage were significantly increased during the dry season (OR 1.5 95% CI 1.4-1.7) and during outbreaks (OR 6.7 95% CI 1.6-29). Meningococcal carriage in the African meningitis belt peaks at a younger age compared to Europe. This is consistent with contact studies in Africa, which show that children 10-14 years have the highest frequency of contacts. Targeting older children in Africa for conjugate vaccination may be effective in reducing meningococcal transmission.
引用
收藏
页数:9
相关论文
共 41 条
[1]   The Diversity of Meningococcal Carriage Across the African Meningitis Belt and the Impact of Vaccination With a Group A Meningococcal Conjugate Vaccine [J].
Ali, Oumer ;
Aseffa, Abraham ;
Bedru, Ahmed ;
Lema, Tsehaynesh ;
Moti, Tesfaye ;
Tekletsion, Yenenesh ;
Worku, Alemayehu ;
Xabher, Haimanot Guebre ;
Yamuah, Lawrence ;
Boukary, Rahamatou Moustapha ;
Collard , Jean-Marc ;
Dano, Ibrahim Dan ;
Habiboulaye, Ibrahim ;
Issaka, Bassira ;
Jusot, Jean-Francois ;
Ousmane, Sani ;
Rabe, Issoufa ;
Daugla , Doumagoum Moto ;
Gami, Jean Pierre ;
Gamougam, Kadidja ;
Mbainadji, Lodoum ;
Naibei, Nathan ;
Narbe, Maxime ;
Toralta, Jacques ;
Berthe, Abdoulaye ;
Diallo, Kanny ;
Keita, Mahamadou ;
Onwuchekwa, Uma ;
Sow , Samba O. ;
Tamboura, Boubou ;
Traore, Awa ;
Toure, Alou ;
Clark, Tom ;
Mayer, Leonard ;
Amodu, Mary ;
Beida, Omeiza ;
Gadzama, Galadima ;
Omotara , Babatunji ;
Sambo, Zailani ;
Yahya, Shuaibu ;
Chandramohan, Daniel ;
Greenwood , Brian M. ;
Hassan-King, Musa ;
Manigart, Olivier ;
Nascimento, Maria ;
Stuart, James M. ;
Woukeu, Arouna ;
Basta, Nicole E. ;
Bai, Xilian ;
Borrow, Ray .
JOURNAL OF INFECTIOUS DISEASES, 2015, 212 (08) :1298-1307
[2]  
[Anonymous], 2014, FITTING LINEAR MIXED
[3]  
[Anonymous], 2017, R LANG ENV STAT COMP
[4]  
[Anonymous], WORLD POP PROSP
[5]  
[Anonymous], PORTAGE RHINOPHARYNG
[6]  
[Anonymous], 2016, SENSORS, V16, pC1, DOI 10.1109/JSEN.2016.2517933
[7]   Methods for Identifying Neisseria meningitidis Carriers: A Multi-Center Study in the African Meningitis Belt [J].
Basta, Nicole E. ;
Stuart, James M. ;
Nascimento, Maria C. ;
Manigart, Olivier ;
Trotter, Caroline ;
Hassan-King, Musa ;
Chandramohan, Daniel ;
Sow, Samba O. ;
Berthe, Abdoulaye ;
Bedru, Ahmed ;
Tekletsion, Yenenesh K. ;
Collard, Jean-Marc ;
Jusot, Jean-Francois ;
Diallo, Aldiouma ;
Bassene, Hubert ;
Daugla, Doumagoum M. ;
Gamougam, Khadidja ;
Hodgson, Abraham ;
Forgor, Abudulai A. ;
Omotara, Babatunji A. ;
Gadzama, Galadima B. ;
Watkins, Eleanor R. ;
Rebbetts, Lisa S. ;
Diallo, Kanny ;
Weiss, Noel S. ;
Halloran, M. Elizabeth ;
Maiden, Martin C. J. ;
Greenwood, Brian .
PLOS ONE, 2013, 8 (10)
[8]   THE EFFECT OF RIFAMPICIN ON MENINGOCOCCAL CARRIAGE IN FAMILY CONTACTS IN NORTHERN NIGERIA [J].
BLAKEBROUGH, IS ;
GILLES, HM .
JOURNAL OF INFECTION, 1980, 2 (02) :137-143
[9]   THE EPIDEMIOLOGY OF INFECTIONS DUE TO NEISSERIA-MENINGITIDIS AND NEISSERIA-LACTAMICA IN A NORTHERN NIGERIAN COMMUNITY [J].
BLAKEBROUGH, IS ;
GREENWOOD, BM ;
WHITTLE, HC ;
BRADLEY, AK ;
GILLES, HM .
JOURNAL OF INFECTIOUS DISEASES, 1982, 146 (05) :626-637
[10]   FAILURE OF MENINGOCOCCAL VACCINATION TO STOP THE TRANSMISSION OF MENINGOCOCCI IN NIGERIAN SCHOOLBOYS [J].
BLAKEBROUGH, IS ;
GREENWOOD, BM ;
WHITTLE, HC ;
BRADLEY, AK ;
GILLES, HM .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1983, 77 (02) :175-178