New alkaloids and diterpenes from a deep ocean sediment derived fungus Penicillium sp.

被引：127

作者：

Du, Lin ^{[1
]}

Li, Dehai ^{[1
]}

Zhu, Tianjiao ^{[1
]}

Cai, Shengxin ^{[1
]}

Wang, Fengping ^{[2
]}

Xiao, Xiang ^{[2
]}

Gu, Qianqun ^{[1
]}

机构：

[1] Ocean Univ China, Inst Marine Drugs & Food, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] State Ocean Adm, Inst Oceanog 3, Key Lab Marine Biogenet Resources, Xiamen, Peoples R China

来源：

TETRAHEDRON | 2009年 / 65卷 / 05期

关键词：

Penicillium sp; Alkaloid; Diterpene; Deep ocean; Fungus; ROQUEFORTINE; OXALINE; BIOSYNTHESIS; METABOLITES; STEREOCHEMISTRY; INHIBITION; NEOXALINE; CULTURES; ASSAY;

D O I：

10.1016/j.tet.2008.11.078

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new alkaloids. including two new meleagrin analogs, meleagrins B (2) and C (3), and two new diketopiperazines, roquefortines F (5) and G (6), together with six new diterpenes, conidiogenones B-G (7-12), were isolated from a deep ocean sediment derived fungus Penicillium sp. The structures and stereochemistry of the new compounds were elucidated by spectroscopic methods. The cytotoxicity of the new compounds against the HL-60, A-549, BEL-7402, and MOLT-4 cell lines was evaluated. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1033 / 1039

页数：7

共 26 条

[1] Molecular requirements for inhibition of cytochrome P450 activities by roquefortine [J].