Lipases:: Useful biocatalysts for the preparation of pharmaceuticals

被引：311

作者：

Gotor-Fernandez, Vicente ^{[1
]}

Brieva, Rosario ^{[1
]}

Gotor, Vicente ^{[1
]}

机构：

[1] Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, Oviedo 33006, Spain

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2006年 / 40卷 / 3-4期

关键词：

biocatalysis; lipases; enzymatic resolution; desymmetrization; pharmaceuticals;

D O I：

10.1016/j.molcatb.2006.02.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biocatalysis offers a clean and ecological way to perform chemical processes, in mild reaction conditions and with high degree of selectivity. The use of enzymes, specially lipases, in organic solvents proves an excellent methodology for the preparation of single-isomer chiral drugs. This review covers some general aspects and representative examples of the use of lipases for the enantioselective or regioselective preparation of alcohol and amine intermediates in the synthesis of pharmaceuticals. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：111 / 120

页数：10

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