An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis

被引：11

作者：

Takhar, J ^{[1
]}

Malla, AK

Siu, V

MacPherson, C

Fan, YS

Townsend, L

机构：

[1] Univ Western Ontario, London Hlth Sci Ctr, Dept Psychiat, London, ON N6A 4G5, Canada

[2] Univ Western Ontario, Med Genet Program, London, ON N6A 4G5, Canada

[3] Univ Western Ontario, London Hlth Sci Ctr, Cytogenet Lab, London, ON N6A 4G5, Canada

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2002年 / 106卷 / 01期

关键词：

chromosome; 21; chromosome deletion; genetics; psychotic disorder;

D O I：

10.1034/j.1600-0447.2002.01323.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Case of an interstitial deletion of the long arm of chromosome 21 presenting with first episode of psychosis. Method: A case report. Results: A 16-year-high school student of Somalian origin presented with a first episode of psychosis, mild mental retardation and dysmorphic features. Chromosome analysis revealed an interstitial deletion in the long arm of chromosome 21, described as 46, XX del (21) (q21q22.1). Conclusion: First episode of psychosis occurred in combination with neurobiological vulnerability and a complex genetic inheritance. The occurrence of psychosis in our case may be attributable to genes located within the region 21q21q22.1. The possibility that other loci exist on chromosome 21, which predispose to schizophrenia has to be considered. Identification of susceptibility genes will greatly facilitate investigation of factors that contribute to the disease process and may lead to early intervention and prevention.

引用

页码：71 / 74

页数：4

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