FOXP3 ensembles in T-cell regulation

被引：63

作者：

Li, Bin ^{[1
]}

Samanta, Arabinda ^{[1
]}

Song, Xiaomin ^{[1
]}

Furuuchi, Keiji ^{[1
]}

Iacono, Kathryn T. ^{[1
]}

Kennedy, Sarah ^{[1
]}

Katsumata, Makoto ^{[1
]}

Saouaf, Sandra J. ^{[1
]}

Greene, Mark I. ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

IMMUNOLOGICAL REVIEWS | 2006年 / 212卷

关键词：

D O I：

10.1111/j.0105-2896.2006.00405.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T-cell activities, and it is our goal to determine how these ensembles regulate FOXP3's transcriptional activity in vivo. In this review, we summarize our current understanding of how FOXP3 expression is induced and how FOXP3 functions in vivo as a transcriptional regulator by assembling a multisubunit complex involved in histone modification as well as chromatin remodeling.

引用

页码：99 / 113

页数：15

共 50 条

[1] Regulatory T-cell development: is Foxp3 the decider?
Curiel, Tyler J.
NATURE MEDICINE, 2007, 13 (03) : 250 - 253
[2] Is FOXP3 expressed in cutaneous T-cell lymphomas?
Banham, Alison H.
Brown, Philip J.
Lyne, Linden
Schulze, Hans-Joachim
Hallermann, Christian
EUROPEAN JOURNAL OF HAEMATOLOGY, 2008, 80 (01) : 90 - 91
[3] Regulatory T-cell development: is Foxp3 the decider?
Tyler J Curiel
Nature Medicine, 2007, 13 : 250 - 253
[4] Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Alexander Marson
Karsten Kretschmer
Garrett M. Frampton
Elizabeth S. Jacobsen
Julia K. Polansky
Kenzie D. MacIsaac
Stuart S. Levine
Ernest Fraenkel
Harald von Boehmer
Richard A. Young
Nature, 2007, 445 : 931 - 935
[5] Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Marson, Alexander
Kretschmer, Karsten
Frampton, Garrett M.
Jacobsen, Elizabeth S.
Polansky, Julia K.
Maclsaac, Kenzie D.
Levine, Stuart S.
Fraenkel, Ernest
von Boehmer, Harald
Young, Richard A.
NATURE, 2007, 445 (7130) : 931 - 935
[6] Foxp3 expression in cutaneous T-cell lymphocytic infiltrates
Solomon, Garron J.
Magro, Cynthia M.
JOURNAL OF CUTANEOUS PATHOLOGY, 2008, 35 (11) : 1032 - 1039
[7] Evaluation of FoxP3 expression in peripheral T-cell lymphoma
Bonzheim, Irina
Geissinger, Eva
Tinguely, Marianne
Roth, Sabine
Grieb, Tina
Reimer, Peter
Wilhelm, Martin
Rosenwald, Andreas
Mueller-Hermelink, Hans Konrad
Ruediger, Thomas
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2008, 130 (04) : 613 - 619
[8] The FOXP3 transcription factor as a regulatory T-cell marker
Banham, A. H.
CYTOMETRY PART B-CLINICAL CYTOMETRY, 2008, 74B (01) : 49 - 50
[9] FOXP3 expression in diverse T-cell lymphomas.
Beltran-Garate, Brady E.
Quinones, Pilar
Morales, Domingo
Huamani-Zavala, Julia
Mejia, Osbert
Vidurrizaga, Miriam
Malaga, Jose
Castillo-Aguirre, Jorge
Riva, Luis
Hurtado de Mendoza, Fernando
Carrasco-Yalan, Antonio A.
BLOOD, 2006, 108 (11) : 273B - 273B
[10] Monitoring regulatory T-cell activity with tide FoxP3 gene
Ramcharran, Luana
Haslett, Patrick A. J.
Worley, Jason
Shrestha, Niraj
Pallin, Maria
Sharpe, Ishmael
ETHNICITY & DISEASE, 2007, 17 (04) : S56 - S57

← 1 2 3 4 5 →