CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis

被引：19

作者：

Zhang, Chen ^{[1
]}

Qiao, Hongjiang ^{[1
]}

Guo, Weinan ^{[1
]}

Liu, Yuan ^{[3
,4
,5
]}

Yang, Luting ^{[1
]}

Liu, Yufeng ^{[1
]}

Jin, Boquan ^{[6
]}

Fu, Meng ^{[1
]}

Wang, Gang ^{[1
]}

Li, Wei ^{[1
,2
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian 710032, Shaanxi, Peoples R China

[2] Fudan Univ, Dept Dermatol, Huashan Hosp, Shanghai 200040, Peoples R China

[3] Fourth Mil Med Univ, State Key Lab Mil Stomatol, Xian 710032, Shaanxi, Peoples R China

[4] Fourth Mil Med Univ, Natl Clin Res Ctr Oral Dis, Xian 710032, Shaanxi, Peoples R China

[5] Fourth Mil Med Univ, Shaanxi Int Joint Res Ctr Oral Dis, Dept Oral Histol & Pathol, Xian 710032, Shaanxi, Peoples R China

[6] Fourth Mil Med Univ, Dept Immunol, Xian 710032, Shaanxi, Peoples R China

来源：

CANCER LETTERS | 2019年 / 455卷

基金：

中国国家自然科学基金;

关键词：

Head and neck squamous cell carcinoma; CD100; Plexin-B1; Snail; Epithelial-mesenchymal transition; Metastasis; SEMAPHORIN; 4D; TUMOR; MIGRATION; PHOSPHORYLATION; PROLIFERATION; ACTIVATION; EXPRESSION; RECEPTORS; PLEXIN-B1; INVASION;

D O I：

10.1016/j.canlet.2019.04.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head and neck squamous cell carcinoma (HNSCC) is one of the most lethal cancers mainly due to the high rate of metastasis. Here, we find that the expression level of CD100 in HNSCC is positively correlated with the T category, pathological grade and lymph node metastasis of the tumor. The level of soluble CD100 (sCD100) is highly increased in serum of HNSCC patients, and sCD100 markedly induces the epithelial-mesenchymal transition (EMT) of HNSCC through its receptor, Plexin-B1 (PlxnB1), and promotes the metastasis in a xenograft mouse model. Furthermore, sCD100 promotes the stabilization of Snail through the regulation of the Vav1-Rac1/RhoA-p21-activated kinase pathway for the induction of EMT. Anti-CD100 antibody abolishes the CD100-induced EMT and prevents the metastasis of HNSCC, and anti-CD100 antibody also increases the drug sensitivity of HNSCC. Taken together, our study shows for the first time that CD100 induces the EMT of HNSCC and promotes the metastasis, and CD100 would be a candidate as a novel prognostic biomarker and a potential therapeutic target for HNSCC.

引用

页码：1 / 13

页数：13

共 38 条

[1] The ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease [J].

Angela Nieto, M. .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27, 2011, 27 :347-376

[2] Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism [J].

Bhowmick, NA ;

Ghiassi, M ;

Bakin, A ;

Aakre, M ;

Lundquist, CA ;

Engel, ME ;

Arteaga, CL ;

Moses, HL .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (01) :27-36

[3] Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway [J].

Brown, JL ;

Stowers, L ;

Baer, M ;

Trejo, J ;

Coughlin, S ;

Chant, J .

CURRENT BIOLOGY, 1996, 6 (05) :598-605

[4] Plexin-B1 and semaphorin 4D cooperate to promote cutaneous squamous cell carcinoma cell proliferation, migration and invasion [J].

Cao, Jiao ;

Zhang, Chen ;

Chen, Ting ;

Tian, Rong ;

Sun, Shuhong ;

Yu, Xianshui ;

Xiao, Chunying ;

Wang, Gang ;

Liu, Yufeng ;

Fu, Meng ;

Li, Wei .

JOURNAL OF DERMATOLOGICAL SCIENCE, 2015, 79 (02) :127-136

[5] Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies [J].

Evans, Elizabeth E. ;

Jonason, Alan S., Jr. ;

Bussler, Holm ;

Torno, Sebold ;

Veeraraghavan, Janaki ;

Reilly, Christine ;

Doherty, Michael A. ;

Seils, Jennifer ;

Winter, Laurie A. ;

Mallow, Crystal ;

Kirk, Renee ;

Howell, Alan ;

Giralico, Susan ;

Scrivens, Maria ;

Klimatcheva, Katya ;

Fisher, Terrence L. ;

Bowers, William J. ;

Paris, Mark ;

Smith, Ernest S. ;

Zauderer, Maurice .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (06) :689-701

[6] Generation and preclinical characterization of an antibody specific for SEMA4D [J].

Fisher, Terrence L. ;

Reilly, Christine A. ;

Winter, Laurie A. ;

Pandina, Tracy ;

Jonason, Alan ;

Scrivens, Maria ;

Balch, Leslie ;

Bussler, Holm ;

Torno, Sebold ;

Seils, Jennifer ;

Mueller, Loretta ;

Huang, He ;

Klimatcheva, Ekaterina ;

Howell, Alan ;

Kirk, Renee ;

Evans, Elizabeth ;

Paris, Mark ;

Leonard, John E. ;

Smith, Ernest S. ;

Zauderer, Maurice .

MABS, 2016, 8 (01) :150-162

[7] NF-B and stat3 transcription factor signatures differentiate HPV-positive and HPV-negative head and neck squamous cell carcinoma [J].

Gaykalova, Daria A. ;

Manola, Judith B. ;

Ozawa, Hiroyuki ;

Zizkova, Veronika ;

Morton, Kathryn ;

Bishop, Justin A. ;

Sharma, Rajni ;

Zhang, Chi ;

Michailidi, Christina ;

Considine, Michael ;

Tan, Marietta ;

Fertig, Elana J. ;

Hennessey, Patrick T. ;

Ahn, Julie ;

Koch, Wayne M. ;

Westra, William H. ;

Khan, Zubair ;

Chung, Christine H. ;

Ochs, Michael F. ;

Califano, Joseph A. .

INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (08) :1879-1889

[8] Rho GTPases and the actin cytoskeleton [J].

Hall, A .

SCIENCE, 1998, 279 (5350) :509-514

[9] Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton [J].

Hartsock, Andrea ;

Nelson, W. James .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2008, 1778 (03) :660-669

[10] Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition [J].

Huang, Wei ;

Cui, Xiuying ;

Chen, Jianing ;

Feng, Yuhuan ;

Song, Erwei ;

Li, Jinsong ;

Liu, Yujie .

ONCOTARGET, 2016, 7 (38) :62520-62532

← 1 2 3 4 →