Antiphospholipid Antibody Syndrome

被引：37

作者：

Kutteh, William H. ^{[1
,2
]}

Hinote, Candace D. ^{[3
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Nashville, TN 37232 USA

[2] Fertil Associates Memphis PLLC, Memphis, TN 38120 USA

[3] MidSouth OB GYN, Memphis, TN 38120 USA

来源：

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA | 2014年 / 41卷 / 01期

关键词：

Antiphospholipid syndrome; Antiphospholipid antibodies; Recurrent pregnancy loss; Fetal demise; Unfractionated heparin; Complications of pregnancy; RECURRENT PREGNANCY LOSS; MOLECULAR-WEIGHT HEPARIN; VITRO TROPHOBLAST INVASIVENESS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; IMMUNOGLOBULIN-G FRACTIONS; LOW-DOSE ASPIRIN; ANTICARDIOLIPIN ANTIBODIES; FETAL LOSS; ENDOTHELIAL-CELLS; RISK-FACTORS;

D O I：

10.1016/j.ogc.2013.10.004

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Antiphospholipid antibodies (aPLs) are acquired antibodies directed against negatively charged phospholipids. Obstetric antiphospholipid antibody syndrome (APS) is diagnosed in the presence of certain clinical features in conjunction with positive laboratory findings. Obstetric APS is one of the most commonly identified causes of recurrent pregnancy loss. Thus, obstetric APS is distinguished from APS in other organ systems where the most common manifestation is thrombosis. Several pathophysiologic mechanisms of action of aPLs have been described. This article discusses the diagnostic and obstetric challenges of obstetric APS, proposed pathophysiologic mechanisms of APS during pregnancy, and the management of women during and after pregnancy.

引用

页码：113 / +

页数：21

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