A study on the antioxidant activities of some new benzazole derivatives

被引：19

作者：

Temiz-Arpaci, O.

Coban, T.

Tekiner-Gulbas, B.

Can-Eke, B.

Yildiz, I. ^{[1
]}

Aki-Sener, E.

Yalcin, I.

Iscan, M.

机构：

[1] Ankara Univ, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Ankara Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-06100 Ankara, Turkey

来源：

ACTA BIOLOGICA HUNGARICA | 2006年 / 57卷 / 02期

关键词：

antioxidant activity; benzazole derivatives; superoxide dismutase; lipid peroxidation; DPPH;

D O I：

10.1556/ABiol.57.2006.2.7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The in vitro antioxidant properties of some new benzazole derivatives (1-10) such as benzoxazoles, benzimidazoles, and benzothiazoles were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, the scavenging of superoxide anion and the stable radical 2,2diphenyl-1-picrylhydrazyl (DPPH). Compounds 1, 2, 4 and 6, showed potent scavenging effect on superoxide radical at 10(-3) M. Compound 8, 5-nitro-2-(phenoxymethyl) benzimidazole, strongly inhibited lipid peroxidation at 10(-3) M concentration.

引用

页码：201 / 209

页数：9

共 37 条

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