New tricks for old dogs: KCNQ expression and role in smooth muscle

被引：85

作者：

Greenwood, Iain A. ^{[1
]}

Ohya, Susumu ^{[2
]}

机构：

[1] Univ London, Div Basic Med Sci, London, England

[2] Nagoya City Univ, Dept Mol & Cellular Pharmacol, Grad Sch Pharmaceut Sci, Nagoya, Aichi, Japan

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2009年 / 156卷 / 08期

基金：

日本学术振兴会;

关键词：

KCNQ; smooth muscle; K(v)7 channels; XE991; retigabine; PORTAL-VEIN MYOCYTES; GATED K+ CHANNELS; POTASSIUM CHANNEL; MOLECULAR DETERMINANTS; ANTICONVULSANT RETIGABINE; DIFFERENTIAL EXPRESSION; CEREBRAL-ARTERIES; ERG CHANNELS; CURRENTS; CELLS;

D O I：

10.1111/j.1476-5381.2009.00131.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ion channels encoded by the KCNQ gene family (K(v)7.1-7.5) are major determinants of neuronal membrane potential and the cardiac action potential. This key physiological role is highlighted by the existence of a number of hereditary disorders caused by mutations to KCNQ genes. Recently, KCNQ gene expression has been identified in vascular and non-vascular smooth muscles. In addition, experiments with an array of pharmacological modulators of KCNQ channels have supported a crucial role for these channels in regulating smooth muscle contractility. This article will provide an overview of present understanding in this nascent area of KCNQ research and will offer guidance as to future directions.

引用

页码：1196 / 1203

页数：8

共 84 条

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