Expression of Cyclooxygenase-2, 12-Lipoxygenase, and Inducible Nitric Oxide Synthase in Head and Neck Squamous Cell Carcinoma

被引：15

作者：

Celenk, Fatih ^{[1
]}

Bayramoglu, Ismet ^{[2
]}

Yilmaz, Akin ^{[3
]}

Menevse, Adnan ^{[3
]}

Bayazit, Yildirim ^{[2
]}

机构：

[1] Gaziantep Univ, Fac Med, Dept Otorhinolaryngol, Gaziantep, Turkey

[2] Gazi Univ, Fac Med, Dept Otorhinolaryngol, Ankara, Turkey

[3] Gazi Univ, Fac Med, Dept Med Biol & Genet, Ankara, Turkey

来源：

JOURNAL OF CRANIOFACIAL SURGERY | 2013年 / 24卷 / 04期

关键词：

Head and neck cancer; inflammation; larynx cancer; cyclooxygenase-2; 12-lipoxygenase; inducible nitric oxide synthase; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ARACHIDONIC-ACID METABOLISM; ENDOTHELIAL GROWTH-FACTOR; TUMOR ANGIOGENESIS; CANCER; INHIBITION; INFLAMMATION; CARCINOGENESIS; PROSTAGLANDINS; LIPOXYGENASES;

D O I：

10.1097/SCS.0b013e31828f2491

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Aim: The objective of this study was to investigate whether cyclooxygenase-2 (COX-2), 12-lipoxygenase (12-LOX), and inducible nitric oxide synthase (iNOS) have a role in carcinogenesis of head and neck squamous cell carcinoma (HNSCC). Materials and Methods: Twenty-two patients with HNSCC were included in the study. Cancer tissues and adjacent normal mucosa were obtained from each patient. Real-time PCR was used to assess the expression of COX-2, 12-LOX, and iNOS. Results: COX-2 and 12-LOX mRNA expressions are significantly increased in HNSCC compared with adjacent normal mucosa. Expression of iNOS was not significantly elevated in overall head and neck cancer tissues compared with normal mucosa. However, iNOS expression was found to be significantly elevated in patients with laryngeal cancer. Conclusion: These data suggest that COX-2 and 12-LOX may play a role in carcinogenesis of head and neck cancer. iNOS as well as COX-2 and 12-LOX may play a role in carcinogenesis of laryngeal cancer.

引用

页码：1114 / 1117

页数：4

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