Interleukin 16 and its function as a CD4 ligand

被引：224
作者：
Center, DM
Kornfeld, H
Cruikshank, WW
机构：
[1] Evans Memorial Dept. of Medicine, Pulmonary Center, Boston Univ. School of Medicine, Boston, MA 02118, 80 E. Concord Street
来源：
IMMUNOLOGY TODAY | 1996年 / 17卷 / 10期
关键词：
D O I：
10.1016/0167-5699(96)10052-I
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The secreted form of interleukin 16 (IL-16) is a 14 kDa protein that multimerizes into homotetramers essential for CD4-dependent signaling and cellular functions. As reviewed here by David Center and colleagues, IL-16 is a chemoattractant factor for all CD4(+) leukocytes and is a competence growth factor for CD4(+) T cells, implying that it might play a role in accumulation and activation of CD4(+) immune cells at sites if inflammation.
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页码：476 / 481
页数：6
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