Efficacy of Moringa oleifera and Aloe vera on Aflatoxin B1-induced hepatotoxicity in rats

The aim of this work was to evaluate the protective effect of the plant products, Moringa oleifera leaf juice, drumstick pulp powder and Aloe vera gel against alflatoxin B1 induced hepatotoxicity in rats. AFB1 treatment at the dose of 50 mu g/kg BW in rats increased the levels of hepatic marker enzymes and lipid peroxidation. products and decreased the circulating antioxidants. Supplementation of Moringa oleifera leaf juice at doses 0.5 ml ml/kg BW and 1.0 ml/kg BW, drumstick pulp powder at doses 2g/kg BW and 3g/kg BW and Aloe vera gel at doses 0.5 ml ml/kg BW and 1.0 ml/kg BW along with AFB1 decreased the hepatic marker enzymes and lipid peroxidation products with a concomitant increase in the levels of antioxidants, vitamin C, vitamin E, beta-carotene and reduced glutathione. Furthermore, the hepatic marker enzymes, lipid peroxidation products and antioxidants in rats supplemented with Moringa oleifera leaf juice at the dose of 1.0 ml/kg BW, drumstick pulp powder at the dose of 3g/kg BW and Aloe vera gel at the dose of 1.0 ml/kg BW were oil par with that of controls fed the standard diet. The study shows that Moringa oleifera leaf juice, drumstick pulp powder and Aloe vera gel could provide protection against AFB1 induced hepatotoxicity in rats.