Terahertz Imaging of Three-Dimensional Dehydrated Breast Cancer Tumors

被引：36

作者：

Bowman, Tyler ^{[1
]}

Wu, Yuhao ^{[2
]}

Gauch, John ^{[2
]}

Campbell, Lucas K. ^{[3
]}

El-Shenawee, Magda ^{[1
]}

机构：

[1] Univ Arkansas, Dept Elect Engn, Bell Engn Ctr 3217, Fayetteville, AR 72701 USA

[2] Univ Arkansas, Dept Comp Sci & Comp Engn, 504 JB Hunt Bldg, Fayetteville, AR 72701 USA

[3] Northwest Arkansas Pathol Associates PA, 390 E Longview St, Fayetteville, AR 72703 USA

来源：

JOURNAL OF INFRARED MILLIMETER AND TERAHERTZ WAVES | 2017年 / 38卷 / 06期

基金：

美国国家科学基金会;

关键词：

Biomedical optics; Medical imaging; Breast cancer; Terahertz imaging;

D O I：

10.1007/s10762-017-0377-y

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This work presents the application of terahertz imaging to three-dimensional formalin-fixed, paraffin-embedded human breast cancer tumors. The results demonstrate the capability of terahertz for in-depth scanning to produce cross section images without the need to slice the tumor. Samples of tumors excised from women diagnosed with infiltrating ductal carcinoma and lobular carcinoma are investigated using a pulsed terahertz time domain imaging system. A time of flight estimation is used to obtain vertical and horizontal cross section images of tumor tissues embedded in paraffin block. Strong agreement is shown comparing the terahertz images obtained by electronically scanning the tumor in-depth in comparison with histopathology images. The detection of cancer tissue inside the block is found to be accurate to depths over 1 mm. Image processing techniques are applied to provide improved contrast and automation of the obtained terahertz images. In particular, unsharp masking and edge detection methods are found to be most effective for three-dimensional block imaging.

引用

页码：766 / 786

页数：21

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