Indocyanine green-loaded hollow mesoporous silica nanoparticles as an activatable theranostic agent

被引：30

作者：

Hong, Suk Ho ^{[1
]}

Kim, Hyunjin ^{[1
]}

Choi, Yongdoo ^{[1
]}

机构：

[1] Natl Canc Ctr, Mol Imaging & Therapy Branch, 323 Ilsan Ro, Goyang Si 10408, Gyeonggi Do, South Korea

来源：

NANOTECHNOLOGY | 2017年 / 28卷 / 18期

基金：

新加坡国家研究基金会;

关键词：

theranostics; activatable; hollow mesoporous silica nanoparticles; photodynamic therapy; nearinfrared; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; DEGRADATION; ABSORPTION; EXPOSURE; SURGERY; CANCER; DYE;

D O I：

10.1088/1361-6528/aa66b0

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Here we report indocyanine green (ICG)-loaded hollow mesoporous silica nanoparticles (ICG@HMSNP) as an activatable theranostic platform. Near-infrared fluorescence and singlet oxygen generation of ICG@HMSNP was effectively quenched (i. e. turned off) in its native state because of the fluorescence resonance energy transfer between ICG molecules. Therefore, ICG@HMSNP was nonfluorescent and nonphototoxic in the extracellular region. After the nanoparticles entered the cancer cells via endocytosis, they became highly fluorescent and phototoxic. In addition, intracellular uptake of ICG@HMSNP was 2.75 times higher than that of free ICG, resulting in an enhanced phototherapy of cancer.

引用

页数：8

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