Cancer immunosurveillance: role of patrolling monocytes

被引：35

作者：

Cassetta, Luca ^{[1
]}

Pollard, Jeffrey W. ^{[1
,2
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, MRC Ctr Reprod Hlth, Edinburgh EH16 4TJ, Midlothian, Scotland

[2] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

来源：

CELL RESEARCH | 2016年 / 26卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

LY6C(-) MONOCYTES; TUMOR-METASTASIS; MACROPHAGES; CELLS;

D O I：

10.1038/cr.2015.144

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Classical inflammatory monocytes and their derivative macrophages promote tumor metastasis whereas CD8(+) T and NK cells restrict tumor growth. In a recent paper published in Science, Hanna and colleagues demonstrate that another monocyte population, nonclassical patrolling monocytes, is enriched in the microvasculature of tumor-challenged lung and reduces tumor metastasis by recruiting NK cells.

引用

页码：3 / 4

页数：2

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