High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research

被引：204

作者：

Fernandes, Tiago G. ^{[1
,2
,5
]}

Diogo, Maria Margarida ^{[5
]}

Clark, Douglas S. ^{[4
]}

Dordick, Jonathan S. ^{[1
,2
,3
]}

Cabral, Joaquim M. S. ^{[5
]}

机构：

[1] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA

[2] Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA

[3] Rensselaer Polytech Inst, Dept Biol, Troy, NY 12180 USA

[4] Univ Calif Berkeley, Dept Chem Engn, Berkeley, CA 94720 USA

[5] Inst Super Tecn, Ctr Biol & Chem Engn, Inst Biotechnol & Bioengn IBB, P-1049001 Lisbon, Portugal

来源：

TRENDS IN BIOTECHNOLOGY | 2009年 / 27卷 / 06期

基金：

美国国家卫生研究院;

关键词：

GENE-FUNCTION; ON-CHIP; CULTURE; ARRAYS; MICROENVIRONMENTS; BIOMATERIALS; ASSAY; DIFFERENTIATION; TECHNOLOGIES; PROTEINS;

D O I：

10.1016/j.tibtech.2009.02.009

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cellular microarrays are powerful experimental tools for high-throughput screening of large numbers of test samples. Miniaturization increases assay throughput while reducing reagent consumption and the number of cells required, making these systems attractive for a wide range of assays in drug discovery, toxicology, stem cell research and potentially therapy. Here, we provide an overview of the emerging technologies that can be used to generate cellular microarrays, and we highlight recent significant advances in the field. This emerging and multidisciplinary approach offers new opportunities for the design and control of stem cells in tissue engineering and cellular therapies and promises to expedite drug discovery in the biotechnology and pharmaceutical industries.

引用

页码：342 / 349

页数：8

共 50 条

[31] Novel colloidal materials for high-throughput screening applications in drug discovery and genomics
Trau, M
Battersby, BJ
ADVANCED MATERIALS, 2001, 13 (12-13) : 975 - +
[32] Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease
Rodboon, Teerapat
Yodmuang, Supansa
Chaisuparat, Risa
Ferreira, Joao N.
SLAS DISCOVERY, 2022, 27 (03) : 151 - 158
[33] High-throughput flow cytometry for drug discovery: principles, applications, and case studies
Ding, Mei
Kaspersson, Karin
Murray, David
Bardelle, Catherine
DRUG DISCOVERY TODAY, 2017, 22 (12) : 1844 - 1850
[34] A Peptide Aldehyde Microarray for High-Throughput Profiling of Cellular Events
Wu, Hao
Ge, Jingyan
Yang, Peng-Yu
Wang, Jigang
Uttamchandani, Mahesh
Yao, Shao Q.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (06) : 1946 - 1954
[35] High-Throughput Imaging for the Discovery of Cellular Mechanisms of Disease
Pegoraro, Gianluca
Misteli, Tom
TRENDS IN GENETICS, 2017, 33 (09) : 604 - 615
[36] 3D cell culture microarray for high-throughput studies of stem cell fate
Fernandes, Tiago G.
Kwon, Seok-Joon
Bale, Shyam Sundhar
Lee, Moo-Yeal
Diogo, Maria Margarida
Clark, Douglas S.
Cabral, Joaquim Ms
Dordick, Jonathan S.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
[37] Three-Dimensional Cell Culture Microarray for High-Throughput Studies of Stem Cell Fate
Fernandes, Tiago G.
Kwon, Seok Joon
Bale, Shyam Sundhar
Lee, Moo-Yeal
Diogo, Maria Margarida
Clark, Douglas S.
Cabral, Joaquim M. S.
Dordick, Jonathan S.
BIOTECHNOLOGY AND BIOENGINEERING, 2010, 106 (01) : 106 - 118
[38] Stem Cell Models for Drug Discovery and Toxicology Studies
Liu, Wenwei
Deng, Yaguang
Liu, Ying
Gong, Wenrong
Deng, Wenbin
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2013, 27 (01) : 17 - 27
[39] Primary Cells and Stem Cells in Drug Discovery: Emerging Tools for High-Throughput Screening
Eglen, Richard
Reisine, Terry
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2011, 9 (02) : 108 - 124
[40] Stem cell bioengineering at the interface of systems-based models and high-throughput platforms
Underhill, Gregory H.
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 2012, 4 (06) : 525 - 545

← 1 2 3 4 5 →