Intracellular calcium involved in the long-term potentiation induced by securinine in dentate gyrus of anesthetized rats

被引：0
|
作者：
Xu, L
Wen, GL
Zhang, JT
机构：
[1] Chinese Acad Med Sci, Dept Pharmacol, Inst Mat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
PLANTA MEDICA | 2002年 / 68卷 / 08期
关键词：
D O I：
暂无
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The effect of nimodipine on securinine-induced long-term potentiation in rat hippocampus was studied. The rise of intracellular calcium during the induction of long-term potentiation was measured using Fura-2/AM - a Ca2+ fluorescent chelator. Results showed that intracerebroventricular injection of nimodipine (4 nmol) blocked the induction of long-term potentiation elicited by securinine (0.4 pmol) and high-frequency stimulation (p < 0.05), but 2-amino-5-phosphonovaleric acid (5 nmol) had no inhibitory effect on securinine-induced long-term potentiation. In addition, securinine-induced intracellular calcium increment was inhibited by nimodipine (10(-6) mol . L-1, p < 0.01), but not by 2-amino-5-phosphonovaleric acid (10(-6) mol . L-1, p > 0.05).
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页码：752 / 753
页数：2
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