IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients

被引：17

作者：

Couturier, Nicolas ^{[1
]}

Gourraud, Pierre-Antoine ^{[2
]}

Cournu-Rebeix, Isabelle ^{[3
]}

Gout, Claire ^{[3
]}

Bucciarelli, Florence ^{[1
]}

Edan, Gilles ^{[4
]}

Babron, Marie-Claude ^{[5
]}

Clerget-Darpoux, Francoise ^{[5
]}

Clanet, Michel ^{[1
]}

Fontaine, Bertrand ^{[3
]}

Brassat, David ^{[1
]}

机构：

[1] Univ Toulouse 3, INSERM, U563, F-31062 Toulouse, France

[2] Univ Toulouse 3, INSERM, Dept Epidemiol & Sante Publ, U558, F-31062 Toulouse, France

[3] Univ Paris 06, INSERM, U546, Paris, France

[4] CHU Pontchaillou, Dept Neurol, Rennes, France

[5] Univ Paris Sud, INSERM, U535, Villejuif, France

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2009年 / 17卷 / 06期

关键词：

IFIH1; multiple sclerosis; interferon-induced protein; autoimmune disease; genetic association study; GENOME-WIDE ASSOCIATION; DIAGNOSTIC-CRITERIA; INTERLEUKIN-7; RECEPTOR; RISK; ALLELES;

D O I：

10.1038/ejhg.2008.259

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent investigation reported, for the first time, an association between variants in the IFIH1-GCA-KCNH7 locus and multiple sclerosis (MS). We sought to replicate this genetic association in MS with a new independent MS cohort composed of French Caucasian MS trio families. The two most significant IFIH1 single nucleotide polymorphisms, rs1990760 and rs2068330, reported as involved in MS susceptibility, were genotyped in 591 French Caucasian MS trio families, and analyzed using the transmission/disequilibrium test. No association with MS was found (rs1990760, P = 0.45 and rs2068330, P = 0.27). Similarly, no significant association was detected after stratification for HLA-DRB1*1501 carriers. Reasons that may explain this discrepancy between the original report and our study are discussed. European Journal of Human Genetics (2009) 17, 844-847; doi: 10.1038/ejhg.2008.259; published online 21 January 2009

引用

页码：844 / 847

页数：4

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