Alzheimer disease and aducanumab: adjusting our approach

被引：163

作者：

Selkoe, Dennis J. ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

NATURE REVIEWS NEUROLOGY | 2019年 / 15卷 / 07期

关键词：

D O I：

10.1038/s41582-019-0205-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In the march towards disease-modifying treatments for Alzheimer disease, immunotherapy with antibodies against amyloid-beta protein is furthest along in human trials. The news that Biogen's aducanumab showed no cognitive benefit in phase III trials requires careful analysis of what went wrong and how to position anti-amyloid agents among other therapeutic approaches.

引用

页码：365 / 366

页数：2

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