Fatal Fusarium infection manifesting as osteomyelitis following previous treatment with amphotericin B in a multi-visceral transplant: Case report and review of Fusarium infections in solid organ transplantation

被引：14
作者：
Nambiar, P. [1 ]
Cober, E. [2 ]
Johnson, L. [2 ]
Brizendine, K. D. [2 ,3 ]
机构：
[1] Louisiana State Univ Hlth Syst, Infect Dis Sect, Dept Med, Shreveport, LA USA
[2] Cleveland Clin, Dept Infect Dis, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Lerner Coll Med, Cleveland Clin, Cleveland, OH 44106 USA
来源：
TRANSPLANT INFECTIOUS DISEASE | 2018年 / 20卷 / 03期
关键词：
Fusarium; osteomyelitis; outcomes; solid organ transplantation; treatment; IMMUNOCOMPROMISED PATIENTS; FUNGAL-INFECTIONS; PATIENT; RECIPIENT; SOLANI; SCEDOSPORIUM; POSACONAZOLE; VORICONAZOLE; MANAGEMENT; FUNGEMIA;
D O I：
10.1111/tid.12872
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Invasive fusariosis in solid organ transplant is uncommon and usually presents as localized infection with favorable outcomes compared to hematologic malignancies or bone marrow transplants. We report the first case of Fusarium osteomyelitis in a patient following multi-visceral transplant and review Fusarium in organ transplant recipients and Fusarium bone and joint infections. Our case underscores the importance of early recognition and multidisciplinary approach to treatment and highlights potential failure to eradicate with amphotericin B monotherapy.
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页数：5
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