Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress

被引：12

作者：

Zhu Ying-Li ^{[1
]}

Wang Lin-Yuan ^{[1
]}

Zhao Dan-Ping ^{[1
]}

Wang Cheng-Long ^{[2
]}

Zhang Rui ^{[2
]}

Fei Wen-Ting ^{[2
]}

Wang Jing-Xia ^{[2
]}

Zhang Jian-Jun ^{[2
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China

[2] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2020年 / 18卷 / 11期

关键词：

Paeonia lactiflora; Albiflorin; Chronic restraint stress; Anti-stress; NO-mediated pathway; DEPRESSION-LIKE BEHAVIOR; GUANOSINE-MONOPHOSPHATE PATHWAY; NITRIC-OXIDE SYNTHASE; HIPPOCAMPAL NEUROGENESIS; SEROTONERGIC SYSTEM; NEUROTROPHIC FACTOR; GUANYLATE-CYCLASE; RECEPTOR-BINDING; ANXIOLYTIC-LIKE; ANIMAL-MODELS;

D O I：

10.1016/S1875-5364(20)60030-9

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg.kg(-1) of AF for 21 d. Control rats were maintained in completely non stressed conditions. Behavioral tests and biochemical analysis were applied to investigating a regulatory mechanism of anti-stress of AF. Treatment with AF significantly restored the depressant-like behaviors. Besides, AF increased the levels of 5-hydroxytryptophan (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), noradrenaline (NE) and dopamine (DA) in the hippocampus and increased the level of brain-derived neurotrophic factor (BDNF) in serum and protein expression in hippocampus. In addition, AF decreased the levels of hypothalamo-pituitary-adrenal (HPA) cascade, reduced the level of NO and cGMP in serum and inhibited the overexpression of 5-HT2AR mRNA and protein expression. Taken together, AF can modulate the NO-mediated network pathway in the hippocampus against stress-induced depressive-like behaviors. These physiological and behavioral changes allow rats to avoid potential deleterious effects of stress that may result from chronically elevated levels of glucocorticosteroids over days.

引用

页码：872 / 880

页数：9

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