Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress

被引：9
作者：
Zhu Ying-Li [1 ]
Wang Lin-Yuan [1 ]
Zhao Dan-Ping [1 ]
Wang Cheng-Long [2 ]
Zhang Rui [2 ]
Fei Wen-Ting [2 ]
Wang Jing-Xia [2 ]
Zhang Jian-Jun [2 ]
机构：
[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China
[2] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2020年 / 18卷 / 11期
关键词：
Paeonia lactiflora; Albiflorin; Chronic restraint stress; Anti-stress; NO-mediated pathway; DEPRESSION-LIKE BEHAVIOR; GUANOSINE-MONOPHOSPHATE PATHWAY; NITRIC-OXIDE SYNTHASE; HIPPOCAMPAL NEUROGENESIS; SEROTONERGIC SYSTEM; NEUROTROPHIC FACTOR; GUANYLATE-CYCLASE; RECEPTOR-BINDING; ANXIOLYTIC-LIKE; ANIMAL-MODELS;
D O I：
10.1016/S1875-5364(20)60030-9
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg.kg(-1) of AF for 21 d. Control rats were maintained in completely non stressed conditions. Behavioral tests and biochemical analysis were applied to investigating a regulatory mechanism of anti-stress of AF. Treatment with AF significantly restored the depressant-like behaviors. Besides, AF increased the levels of 5-hydroxytryptophan (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), noradrenaline (NE) and dopamine (DA) in the hippocampus and increased the level of brain-derived neurotrophic factor (BDNF) in serum and protein expression in hippocampus. In addition, AF decreased the levels of hypothalamo-pituitary-adrenal (HPA) cascade, reduced the level of NO and cGMP in serum and inhibited the overexpression of 5-HT2AR mRNA and protein expression. Taken together, AF can modulate the NO-mediated network pathway in the hippocampus against stress-induced depressive-like behaviors. These physiological and behavioral changes allow rats to avoid potential deleterious effects of stress that may result from chronically elevated levels of glucocorticosteroids over days.
引用
收藏
页码：872 / 880
页数：9
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