White Matter by Diffusion MRI Following Methylphenidate Treatment: A Randomized Control Trial in Males with Attention-Deficit/Hyperactivity Disorder

被引:45
作者
Bouziane, Cheima [1 ,2 ,3 ,4 ]
Filatova, Olena G. [5 ]
Schrantee, Anouk [1 ,2 ,3 ,4 ,6 ]
Caan, Matthan W. A. [1 ,2 ,3 ,4 ]
Vos, Frans M. [1 ,2 ,3 ,4 ,5 ]
Reneman, Liesbeth [1 ,2 ,3 ,4 ,6 ]
机构
[1] Univ Amsterdam, Locat AMC, Amsterdam Univ Med Ctr, Dept Radiol, G1-222 Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Locat AMC, Amsterdam Univ Med Ctr, Dept Nucl Med, G1-222 Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Amsterdam, Locat AMC, Amsterdam Univ Med Ctr, Dept Biomed Engn, G1-222 Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
[4] Univ Amsterdam, Locat AMC, Amsterdam Univ Med Ctr, Dept Phys, G1-222 Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
[5] Delft Univ Technol, Dept Imaging Phys, Delft, Netherlands
[6] Amsterdam Neurosci, Amsterdam, Netherlands
关键词
BRAIN; CHILDREN; ADOLESCENCE; CHILDHOOD;
D O I
10.1148/radiol.2019182528
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background: Methylphenidate (MPH) is highly effective in treating attention-deficit/hyperactivity disorder (ADHD). However, not much is known about its effect on the development of human brain white matter (WM). Purpose: To determine whether MPH modulates WM microstructure in an age-dependent fashion in a randomized double-blind placebo-controlled trial (Effects of Psychotropic Medication on Brain Development-Methylphenidate, or ePOD-MPH) among ADHD referral centers between October 13, 2011, and June 15, 2015, by using diffusion-tensor imaging (DTI). Materials and Methods: In this prospective study (NTR3103 and NL34509.000.10), 50 stimulant treatment-naive boys and 49 young adult men diagnosed with ADHD (all types) according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria were randomized to undergo treatment with MPH or placebo for 16 weeks. Before and 1 week after treatment cessation, study participants underwent MRI, including DTI. The outcome measure was change in fractional anisotropy (FA), which was assessed in three regions of interest (ROIs), as well as in a voxel-based analysis in brain WM. Data were analyzed by using intention-to-treatlinear mixed models for ROI analysis and a permutation-based method for voxel-based analysis with family-wise error correction. Results: Fifty boys (n = 25 MPH group, n = 25 placebo group; age range, 10-12 years) and 48 men (n = 24 MPH group, n = 24 placebo group; age range, 23-40 years) were included. ROI analysis of FA yielded no main effect of time in any of the conditions. However, voxel-based analysis revealed significant (P < .05) time-by-medication-by-age interaction effects in several association tracts of the left hemisphere, as well as in the lateral aspect of the truncus of the corpus callosum, due to greater increase in FA (standardized effect size, 5.25) in MPH-treated boys. Similar changes were not present in boys receiving a placebo, nor in adult men. Conclusion: Four months of treatment with methylphenidate affects specific tracts in brain white matter in boys with attention-deficit/hyperactivity disorder. These effects seem to be age dependent, because they were not observed in adults treated with methylphenidate. (C) RSNA, 2019
引用
收藏
页码:186 / 192
页数:7
相关论文
共 27 条
[1]   Methylphenidate administration to adolescent rats determines plastic changes on reward-related behavior and striatal gene expression [J].
Adriani, Walter ;
Leo, Damiana ;
Greco, Dario ;
Rea, Monica ;
di Porzio, Umberto ;
Laviola, Giovanni ;
Perrone-Capano, Carla .
NEUROPSYCHOPHARMACOLOGY, 2006, 31 (09) :1946-1956
[2]  
[Anonymous], 2010, Diagnostic Interview for ADHD in adults (DIVA)
[3]   White matter development during childhood and adolescence: A cross-sectional diffusion tensor imaging study [J].
Barnea-Goraly, N ;
Menon, V ;
Eckert, M ;
Tamm, L ;
Bammer, R ;
Karchemskiy, A ;
Dant, CC ;
Reiss, AL .
CEREBRAL CORTEX, 2005, 15 (12) :1848-1854
[4]   The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design [J].
Bottelier, Marco A. ;
Schouw, Marieke L. J. ;
Klomp, Anne ;
Tamminga, Hyke G. H. ;
Schrantee, Anouk G. M. ;
Bouziane, Cheima ;
de Ruiter, Michiel B. ;
Boer, Frits ;
Ruhe, Henricus G. ;
Denys, Damiaan ;
Rijsman, Roselyne ;
Lindauer, Ramon J. L. ;
Reitsma, Hans B. ;
Geurts, Hilde M. ;
Reneman, Liesbeth .
BMC PSYCHIATRY, 2014, 14
[5]   ADHD and maturation of brain white matter: A DTI study in medication naive children and adults [J].
Bouziane, Cheima ;
Caan, Matthan W. A. ;
Tamminga, Hyke G. H. ;
Schrantee, Anouk ;
Bottelier, Marco A. ;
de Ruiter, Michiel B. ;
Kooij, Sandra J. J. ;
Reneman, Liesbeth .
NEUROIMAGE-CLINICAL, 2018, 17 :53-59
[6]   Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder [J].
Castellanos, FX ;
Lee, PP ;
Sharp, W ;
Jeffries, NO ;
Greenstein, DK ;
Clasen, LS ;
Blumenthal, JD ;
James, RS ;
Ebens, CL ;
Walter, JM ;
Zijdenbos, A ;
Evans, AC ;
Giedd, JN ;
Rapoport, JL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (14) :1740-1748
[7]   Improving alignment in Tract-based spatial statistics: Evaluation and optimization of image registration [J].
de Groot, Marius ;
Vernooij, Meike W. ;
Klein, Stefan ;
Ikram, M. Arfan ;
Vos, Frans M. ;
Smith, Stephen M. ;
Niessen, Wiro J. ;
Andersson, Jesper L. R. .
NEUROIMAGE, 2013, 76 (01) :400-411
[8]   A prospective cohort study on sustained effects of low-dose ecstasy use on the brain in new ecstasy users [J].
de Win, Maartje M. L. ;
Reneman, Liesbeth ;
Jager, Gerry ;
Vlieger, Erik-Jan P. ;
Olabarriaga, Silvia D. ;
Lavini, Cristina ;
Bisschops, Ivo ;
Majoie, Charles B. L. M. ;
Booij, Jan ;
den Heeten, Gerard J. ;
van den Brink, Wim .
NEUROPSYCHOPHARMACOLOGY, 2007, 32 (02) :458-470
[9]   Diffusion Tensor Imaging: A Review for Pediatric Researchers and Clinicians [J].
Feldman, Heidi M. ;
Yeatman, Jason D. ;
Lee, Eliana S. ;
Barde, Laura H. F. ;
Gaman-Bean, Shayna .
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, 2010, 31 (04) :346-356
[10]  
Ferdinand RF, 2000, NIMH DISC 4 DIAGNOST