Nickel-Catalyzed Regioselective Hydroarylation of Internal Enamides

被引：20

作者：

Wang, Chenchen ^{[1
,2
]}

Xi, Yang ^{[1
,2
]}

Huang, Wenyi ^{[1
,2
]}

Qu, Jingping ^{[1
,2
]}

Chen, Yifeng ^{[1
,2
]}

机构：

[1] East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat,Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn,Sch Chem, Shanghai 200237, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 23期

基金：

中国国家自然科学基金;

关键词：

DIRECT ARYLATION; CYCLIC ENAMIDES; ALKENES; FUNCTIONALIZATION; HYDROALKYNYLATION; HYDROAMINATION; DERIVATIVES; CYCLIZATION; MECHANISM; IRIDIUM;

D O I：

10.1021/acs.orglett.0c03542

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we disclose a nickel-catalyzed three-component reaction of internal enamide, diethoxymethylsilane, and aryl iodide to provide expedient access to benzylic amide derivatives. The protocol features a broad substrate scope with a moderate to excellent isolated yield under the mild condition. The high regioselectivity of Ni-catalyzed enamide hydroarylation can be attributed to the directing effect by the prefunctionalized nitrogen-containing group on the alkenes.

引用

页码：9319 / 9324

页数：6

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