N-Acetyl cysteine (NAC)-mediated reinforcement of alpha-tricalcium phosphate/silk fibroin (α-TCP/SF) cement

被引：12

作者：

Feng, Tao ^{[1
]}

Pi, Bin ^{[1
]}

Li, Bin ^{[2
]}

Jiang, Lei ^{[1
]}

Wang, Yi-Meng ^{[1
]}

Zhu, Xue-Song ^{[1
]}

Yang, Hui-Lin ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Dept Orthoped Surg, Suzhou 215006, Peoples R China

[2] Soochow Univ, Inst Orthoped, Suzhou 215006, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2015年 / 136卷

基金：

中国国家自然科学基金;

关键词：

alpha-Tricalcium phosphate; Silk fibroin; NAC; Mechanical reinforcement; Biocompatibility; CALCIUM-PHOSPHATE; SILK FIBROIN; BONE CEMENTS; MECHANICAL-PROPERTIES; SETTING PROPERTIES; IN-VIVO; DIFFERENTIATION; HYDROXYAPATITE; DELIVERY;

D O I：

10.1016/j.colsurfb.2015.10.021

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Calcium phosphate cements (CPCs) are popular bone filling materials and drug carriers. However poor mechanical properties and lack of osteoinduction restrict their clinical applications. Recent studies suggested the osteogenic properties of NAC. In our study, we incorporated NAC with alpha-TCP/SF. We found that the compressive strength of alpha-TCP/SF-NAC composites increased with increase in NAC concentration, possibly due to complex three-dimensional networks of SF induced by NAC, which was large and chemically heterogeneous and induced compact oriented growth of HA crystals. However the setting time increased slightly with the addition of NAC, due to the ruptured disulfide bonds in SF. The alpha-TCP/SF-NAC composites also showed decent biocompatibility in vitro. As a result, these composites hold great potential as bone filling materials for clinical applications, including minimally invasive surgeries. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：892 / 899

页数：8

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