RETRACTED: Vitamin D receptor (VDR) promoter targeting through a novel chromatin remodeling complex (Retracted article. See vol. 126, pg. 55, 2011)

被引：20

作者：

Kato, S

Fujiki, R

Kitagawa, H

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[2] Japan Sci & Technol, SOREST, Kawaguchi, Saitama 3320012, Japan

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2004年 / 89-90卷 / 1-5期

关键词：

vitamin D receptor; WINAC; histone acetyltransferase; chromatin remodeling;

D O I：

10.1016/j.jsbmb.2004.03.100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have purified nuclear complexes for Vitamin D receptor (VDR), and identified one of them as a novel ATP-dependent chromatine remodeling containing Williams syndrome transcription factor (WSTF), that is supposed to be responsible for Williams syndrome. This complex (WSTF including nucleosome assembly complex (WINAC)) exhibited an ATP-dependent chromatin remodeling activity in vitro. Transient expression assays revealed that WINAC potentiates ligand-induced function of VDR in gene activation and repression. Thus, this study describes a molecular basis of the VDR function on chromosomal DNA through chromatine remodeling. sigma 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：173 / 178

页数：6

相关论文

共 22 条

[1] Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes [J].

Belandia, B ;

Orford, RL ;

Hurst, HC ;

Parker, MG .

EMBO JOURNAL, 2002, 21 (15) :4094-4103

[2] Recruitment of HAT complexes by direct activator interactions with the ATM-related tra1 subunit [J].

Brown, CE ;

Howe, L ;

Sousa, K ;

Alley, SC ;

Carrozza, MJ ;

Tan, S ;

Workman, JL .

SCIENCE, 2001, 292 (5525) :2333-2337

[3] Specificity of gene regulation [J].

Emerson, BM .

CELL, 2002, 109 (03) :267-270

[4] The many faces of chromatin remodeling: SWItching beyond transcription [J].

Fyodorov, DV ;

Kadonaga, JT .

CELL, 2001, 106 (05) :523-525

[5] Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes [J].

Hassan, AH ;

Prochasson, P ;

Neely, KE ;

Galasinski, SC ;

Chandy, M ;

Carrozza, MJ ;

Workman, JL .

CELL, 2002, 111 (03) :369-379

[6] ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor [J].

Ito, T ;

Bulger, M ;

Pazin, MJ ;

Kobayashi, R ;

Kadonaga, JT .

CELL, 1997, 90 (01) :145-155

[7] A novel family of bromodomain genes [J].

Jones, MH ;

Hamana, N ;

Nezu, J ;

Shimane, M .

GENOMICS, 2000, 63 (01) :40-45

[8] RETRACTED: The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome (Retracted article. See vol. 149, pg. 245, 2012) [J].

Kitagawa, H ;

Fujiki, R ;

Yoshimura, K ;

Mezaki, Y ;

Uematsu, Y ;

Matsui, D ;

Ogawa, S ;

Unno, K ;

Okubo, M ;

Tokita, A ;

Nakagawa, T ;

Ito, T ;

Ishimi, Y ;

Nagasawa, H ;

Matsumoto, T ;

Yanagisawa, J ;

Kato, S .

CELL, 2003, 113 (07) :905-917

[9] Selectivity of chromatin-remodelling cofactors for ligand-activated transcription [J].

Lemon, B ;

Inouye, C ;

King, DS ;

Tjian, R .

NATURE, 2001, 414 (6866) :924-928

[10] Requirement of RSF and FACT for transcription of chromatin templates in vitro [J].

LeRoy, G ;

Orphanides, G ;

Lane, WS ;

Reinberg, D .

SCIENCE, 1998, 282 (5395) :1900-1904