Synthesis and biological evaluation of type VI β-turn templated RGD peptidomimetics

被引：11

作者：

Creighton, Christopher J. ^{[1
]}

Du, Yanming ^{[1
]}

Santulli, Rosemary J. ^{[1
]}

Tounge, Brett A. ^{[1
]}

Reitz, Allen B. ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev, Spring House, PA 19477 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 15期

关键词：

beta turn; scaffold; peptidomimetic; RGD;

D O I：

10.1016/j.bmcl.2006.05.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the design, synthesis, and binding affinities of a family of cyclic RGD peptides attached to type VI P-turn scaffolds. The analogues prepared exhibit interesting binding data to the isolated receptors alpha(v)beta(3) and alpha(v)beta(5). The results demonstrate the utility of these type VI P-turn scaffolds for the constraint of biologically relevant peptides. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3971 / 3974

页数：4

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