Heterosynaptic long-term depression in the hippocampus

被引：10

作者：

Scanziani, M

Nicoll, RA

Malenka, RC

机构：

[1] UNIV CALIF SAN FRANCISCO,LANGLEY PORTER PSYCHIAT INST,DEPT PSYCHIAT,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT MOL & CELLULAR PHARMACOL,SAN FRANCISCO,CA 94143

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1996年 / 90卷 / 3-4期

关键词：

asynchrony; heterosynaptic plasticity; long-term depression; hippocampal slice; calcium channel; phosphatase inhibitor;

D O I：

10.1016/S0928-4257(97)81416-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Heterosynaptic long-term depression (hetLTD) at one input can be induced by applying a conditioning stimulus to an adjacent set of synapses. In hippocampal CA1 pyramidal cells, our results suggest that hetLTD is triggered by an extracellular diffusible factor that is released following tetanic activation of NMDA receptors. This hetLTD occludes with homosynaptic LTD suggesting common underlying mechanisms.

引用

页码：165 / 166

页数：2