Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study

被引：48

作者：

Xiao, Q. ^{[1
]}

Freedman, N. D. ^{[1
]}

Ren, J. ^{[2
]}

Hollenbeck, A. R. ^{[3
]}

Abnet, C. C. ^{[1
]}

Park, Y. ^{[1
]}

机构：

[1] NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[2] Natl Canc Ctr, Natl Off Canc Prevent & Control, Beijing, Peoples R China

[3] AARP, Washington, DC USA

来源：

BRITISH JOURNAL OF CANCER | 2014年 / 110卷 / 05期

关键词：

folate; one-carbon metabolism pathway; esophageal cancer; gastric cancer; HEALTH-AMERICAN-ASSOCIATION; RETIRED-PERSONS DIET; NATIONAL-INSTITUTES; NUTRIENT INTAKE; ADENOCARCINOMAS; POLYMORPHISMS; CARCINOMA; OBESITY; MTHFR;

D O I：

10.1038/bjc.2014.17

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Nutrients in the one-carbon metabolism pathway may be involved in carcinogenesis. Few cohort studies have investigated the intakes of folate and related nutrients in relation to gastric and esophageal cancer. Methods: We prospectively examined the association between self-reported intakes of folate, methionine, vitamin B6, and vitamin B12 and gastric and esophageal cancer in 492 293 men and women. Results: We observed an elevated risk of esophageal squamous cell carcinoma with low intake of folate (relative risk (95% confidence interval): Q1 vs Q3, 1.91 (1.17, 3.10)), but no association with high intake. Folate intake was not associated with esophageal adenocarcinoma, gastric cardia adenocarcinoma, or non-cardia gastric adenocarcinoma. The intakes of methionine, vitamin B6, and vitamin B12 were not associated with esophageal and gastric cancer. Conclusion: Low intake of folate was associated with increased risk of esophageal squamous cell carcinoma.

引用

页码：1328 / 1333

页数：6

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