Interleukin-6 receptor blocking with intravenous tocilizumab in COVID-19 severe acute respiratory distress syndrome: A retrospective case-control survival analysis of 128 patients

被引：55

作者：

Canziani, Lorenzo M. ^{[1
,2
]}

Trovati, Serena ^{[2
]}

Brunetta, Enrico ^{[3
]}

Testa, Amidio ^{[2
]}

De Santis, Maria ^{[4
]}

Bombardieri, Emilio ^{[5
]}

Guidelli, Giacomo ^{[4
]}

Albano, Giovanni ^{[6
]}

Folci, Marco ^{[7
]}

Squadroni, Michela ^{[8
]}

Beretta, Giordano D. ^{[8
]}

Ciccarelli, Michele ^{[9
]}

Castoldi, Massimo ^{[10
]}

Lleo, Ana ^{[1
,7
]}

Aghemo, Alessio ^{[1
,7
]}

Vernile, Laura ^{[11
]}

Malesci, Alberto ^{[1
,12
]}

Omodei, Paolo ^{[12
]}

Angelini, Claudio ^{[3
]}

Badalamenti, Salvatore ^{[3
]}

Cecconi, Maurizio ^{[1
,13
]}

Cremonesi, Alberto ^{[1
,14
]}

Selmi, Carlo ^{[1
,4
]}

机构：

[1] Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, MI, Italy

[2] Humanitas Gavasseni, Internal Med, Bergamo, BG, Italy

[3] Humanitas Clin & Res Ctr IRCCS, Gen Med & Nephrol, Rozzano, MI, Italy

[4] Humanitas Clin & Res Ctr IRCCS, Rheumatol & Clin Immunol, Rozzano, MI, Italy

[5] Humanitas Gavazzeni, Sci Direct, Bergamo, BG, Italy

[6] Humanitas Gavazzeni, Anesthesiol & Intens Care, Bergamo, BG, Italy

[7] Humanitas Clin & Res Ctr IRCCS, Gen Med & Hepatol, Rozzano, MI, Italy

[8] Humanitas Gavazzeni, Med Oncol, Bergamo, BG, Italy

[9] Humanitas Clin & Res Ctr IRCCS, Gen Med & Pulmonol, Rozzano, MI, Italy

[10] Humanitas Gavazzeni, Med Direct, Bergamo, BG, Italy

[11] Humanitas Gavazzeni, Pharm, Bergamo, BG, Italy

[12] Humanitas Clin & Res Ctr IRCCS, Gen Med & Gastroenterol, Rozzano, MI, Italy

[13] Humanitas Clin & Res Ctr IRCCS, Anesthesiol & Intens Care, Rozzano, MI, Italy

[14] Humanitas Gavazzeni, Cardiol, Bergamo, BG, Italy

来源：

JOURNAL OF AUTOIMMUNITY | 2020年 / 114卷

关键词：

SARS-Cov-2; Interstitial pneumonia; Intubation; NONLINEAR IMPUTATION;

D O I：

10.1016/j.jaut.2020.102511

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In cases of COVID-19 acute respiratory distress syndrome, an excessive host inflammatory response has been reported, with elevated serum interleukin-6 levels. In this multicenter retrospective cohort study we included adult patients with COVID-19, need of respiratory support, and elevated C-reactive protein who received intravenous tocilizumab in addition to standard of care. Control patients not receiving tocilizumab were matched for sex, age and respiratory support. We selected survival as the primary endpoint, along with need for invasive ventilation, thrombosis, hemorrhage, and infections as secondary endpoints at 30 days. We included 64 patients with COVID-19 in the tocilizumab group and 64 matched controls. At baseline the tocilizumab group had longer symptom duration (13 +/- 5 vs. 9 +/- 5 days) and received hydroxychloroquine more often than controls (100% vs. 81%). The mortality rate was similar between groups (27% with tocilizumab vs. 38%) and at multivariable analysis risk of death was not significantly influenced by tocilizumab (hazard ratio 0.61, 95% confidence interval 0.33-1.15), while being associated with the use at baseline of non invasive mechanical or invasive ventilation, and the presence of comorbidities. Among secondary outcomes, tocilizumab was associated with a lower probability of requiring invasive ventilation (hazard ratio 0.36, 95% confidence interval 0.16-0.83; P = 0.017) but not with the risk of thrombosis, bleeding, or infections. The use of intravenous tocilizumab was not associated with changes in 30-day mortality in patients with COVID-19 severe respiratory impairment. Among the secondary outcomes there was less use of invasive ventilation in the tocilizumab group.

引用

页数：6

共 33 条

[21] Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? [J].