High-dose therapy and autologous stem cell transplantation for extra-nodal NK/T lymphoma in patients from the Western hemisphere: a study from the European Society for Blood and Marrow Transplantation

被引：42

作者：

Fox, Christopher P. ^{[1
]}

Boumendil, Ariane ^{[2
]}

Schmitz, Norbert ^{[2
,3
]}

Finel, Herve ^{[2
]}

Luan, Jian J. ^{[2
]}

Sucak, Gulsan ^{[4
]}

Blaise, Didier ^{[5
]}

Finke, Juergen ^{[6
]}

Pflueger, Karl-Heinz ^{[7
]}

Veelken, Hendrik ^{[8
]}

Gorin, Norbert-Claude ^{[9
,10
]}

Poire, Xavier ^{[11
]}

Ganser, Arnold ^{[12
]}

Dreger, Peter ^{[2
,13
]}

Sureda, Anna ^{[2
,14
]}

机构：

[1] Univ Nottingham Hosp, Clin Haematol, Nottingham NG7 2UH, England

[2] EBMT Lymphoma Working Party, Paris, France

[3] Asklepios Klin St Georg Hamburg, Dept Haematol, Hamburg, Germany

[4] Gazi Univ, Sch Med, Dept Haematol, Ankara, Turkey

[5] Inst J Paoli I Calmettes, Dept Haematol, F-13009 Marseille, France

[6] Univ Hosp Freiburg, Dept Haematol & Oncol, Freiburg, Germany

[7] DIAKO Bremen, Dept Oncol Haematol, Bremen, Germany

[8] Leiden Univ, Med Ctr, Dept Haematol, Leiden, Netherlands

[9] Hop St Antoine, Dept Haematol, F-75571 Paris, France

[10] UPMC, Paris, France

[11] Clin Univ St Luc, Dept Haematol, B-1200 Brussels, Belgium

[12] Hannover Med Sch, Dept Haematol Haemostasis Oncol & Stem Cell Trans, Hannover, Germany

[13] Heidelberg Univ, Dept Med 5, D-69115 Heidelberg, Germany

[14] Cambridge Univ Hosp NHS Trust, Dept Haematol, Cambridge, England

来源：

LEUKEMIA & LYMPHOMA | 2015年 / 56卷 / 12期

关键词：

Epstein-Barr virus; high-dose therapy; natural killer cell lymphoma; stem cell transplantation; NATURAL KILLER/T-CELL; PERIPHERAL T-CELL; NASAL-TYPE; L-ASPARAGINASE; CHEMOTHERAPY; STAGE; RADIOTHERAPY; MANAGEMENT; SMILE;

D O I：

10.3109/10428194.2015.1037764

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extra-nodal NK/T lymphoma (ENKTL) is rare and more frequently encountered in East Asia. The role of high-dose therapy and autologous stem cell transplantation (HDT-ASCT) for ENKTL is unclear. Twenty-eight evaluable patients who had undergone HDT-ASCT in Europe from 2000-2009 were studied. The median age was 47 years and patients had received a median of two lines of prior therapy. Some 57% of patients were not in complete remission or beyond first complete remission at HDT-ASCT. The 1-year non-relapse mortality (NRM) was 11%; 2-year progression-free survival (PFS) and overall survival (OS) rates were 41% and 52%, respectively. Notably, the 2-year PFS and OS for those with stage III/IV disease were 33% and 40%, respectively, with no relapses beyond 1-year post-HDT-ASCT. This is the largest analysis of HDT-ASCT for patients with ENKTL reported from the Western hemisphere. Survival is comparable to East Asian cohorts and outcomes are encouraging for patients with advanced disease.

引用

页码：3295 / 3300

页数：6

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