Clonal nature of odontogenic tumours

被引：17

作者：

Gomes, Carolina Cavalieri ^{[1
]}

Oliveira, Carla da Silveira ^{[1
]}

Castro, Wagner Henriques ^{[1
]}

Tanos de Lacerda, Julio Cesar ^{[2
]}

Gomez, Ricardo Santiago ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Odontol, Mol Biol Lab, Sch Dent,Dept Oral Surg & Pathol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Hosp Odilon Behrens, Belo Horizonte, MG, Brazil

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2009年 / 38卷 / 04期

关键词：

clonality; HUMARA; odontogenic tumours; X-CHROMOSOME; MOLECULAR EVIDENCE; GENE; INACTIVATION; METHYLATION; EXPRESSION; ORIGIN; ARISE; CELLS;

D O I：

10.1111/j.1600-0714.2008.00744.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Although clonal origin is an essential step in the comprehension of neoplasias, there have been no studies to examine whether odontogenic tumours are derived from a single somatic progenitor cell. The purpose of this study was to investigate the clonal origin of odontogenic tumours. Fresh samples of seven ameloblastomas, two odontogenic mixomas, two adenomatoid odontogenic tumour, one calcifying odontogenic cyst, one calcifying epithelial odontogenic tumour (CEOT) and six odontogenic keratocyst (OKC) of female patients were included in this study. After DNA extraction, the HUMARA gene polymorphism assay was performed. Most of the informative odontogenic lesions studied (12 out of 16) showed a monoclonal pattern. Among the polyclonal cases, two were OKC, one CEOT and one odontogenic mixoma. Our results suggest that most odontogenic tumours are monoclonal.

引用

页码：397 / 400

页数：4

共 27 条

[1] DO CANCERS ARISE FROM A SINGLE TRANSFORMED-CELL OR IS MONOCLONALITY OF TUMORS A LATE EVENT IN CARCINOGENESIS [J].

ALEXANDER, P .

BRITISH JOURNAL OF CANCER, 1985, 51 (04) :453-457

[2]

ALLEN RC, 1992, AM J HUM GENET, V51, P1229

[3]

Barnes L., 2005, World Health Organisation classification of tumours. Pathology and genetics of tumours of the head and neck

[4] PTCH gene mutations in odontogenic keratocysts [J].

Barreto, DC ;

Gomez, RS ;

Bale, AE ;

Boson, WL ;

De Marco, L .

JOURNAL OF DENTAL RESEARCH, 2000, 79 (06) :1418-1422

[5]

Belmont JW, 1996, AM J HUM GENET, V58, P1101

[6] NORMAL HUMAN FEMALE AS A MOSAIC OF X-CHROMOSOME ACTIVITY - STUDIES USING GENE FOR G-6-PD-DEFICIENCY AS A MARKER [J].

BEUTLER, E ;

FAIRBANKS, VF ;

YEH, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1962, 48 (01) :9-&

[7] X-linked clonality testing: interpretation and limitations [J].

Chen, George L. ;

Prchal, Josef T. .

BLOOD, 2007, 110 (05) :1410-1419

[8] CLONAL ANALYSIS OF HUMAN COLORECTAL TUMORS [J].

FEARON, ER ;

HAMILTON, SR ;

VOGELSTEIN, B .

SCIENCE, 1987, 238 (4824) :193-197

[9]

Garcia SB, 1999, J PATHOL, V187, P61, DOI 10.1002/(SICI)1096-9896(199901)187:1<61::AID-PATH247>3.0.CO

[10]

2-I

← 1 2 3 →