The impact of the Cancer Genome Atlas on lung cancer

被引：92

作者：

Chang, Jeremy T. -H.

Lee, Yee Ming

Huang, R. Stephanie

机构：

[1] Univ Chicago, Biol Sci Collegiate Div, Chicago, IL 60637 USA

[2] Univ Chicago, Ctr Personalized Therapeut, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Med, Chicago, IL 60637 USA

来源：

TRANSLATIONAL RESEARCH | 2015年 / 166卷 / 06期

关键词：

MESSENGER-RNA; COPY NUMBER; TRANSCRIPTIONAL REGULATION; 1ST-LINE TREATMENT; TUMOR-SUPPRESSOR; OPEN-LABEL; EXPRESSION; GENE; CHEMOTHERAPY; MUTATION;

D O I：

10.1016/j.trsl.2015.08.001

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The Cancer Genome Atlas (TCGA) has profiled more than 10,000 samples derived from 33 types of cancer to date, with the goal of improving our understanding of the molecular basis of cancer and advancing our ability to diagnose, treat, and prevent cancer. This review focuses on lung cancer as it is the leading cause of cancer-related mortality worldwide in both men and women. Particularly, non-small cell lung cancers (including lung adenocarcinoma and lung squamous cell carcinoma) were evaluated. Our goal was to demonstrate the impact of TCGA on lung cancer research under 4 themes: diagnostic markers, disease progression markers, novel therapeutic targets, and novel tools. Examples are given related to DNA mutation, copy number variation, messenger RNA, and microRNA expression along with methylation profiling.

引用

页码：568 / 585

页数：18

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