Combination treatment of rheumatoid arthritis with cyclosporine and methotrexate

被引：0
作者：
Stein, CM
Pincus, T
机构：
[1] Vanderbilt Univ, Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Med, Div Rheumatol, Nashville, TN 37232 USA
来源：
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 1999年 / 17卷 / 06期
关键词：
cyclosporine; methotrexate; combination therapy; rheumatoid arthritis;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In patients with rheumatoid arthritis (RA) not controlled on methotrexate (MTX) alone, clinical trials have shown that combination therapy with cyclosporine (CSA) and MTX is effective and relatively well tolerated over 12 months. Information regarding the long-term benefits, toxicities and tolerability of this combination therapy in clinical practice, and comparisons with alternative strategies, will determine the utility of the MTX plus CSA combination regimen in patients with RA not controlled with a single drug.
引用
收藏
页码：S47 / S52
页数：6
相关论文
共 38 条
  • [21] The underestimated long term medical and economic consequences of rheumatoid arthritis
    Pincus, T
    [J]. DRUGS, 1995, 50 : 1 - 14
  • [22] PINCUS T, 1995, J RHEUMATOL, V22, P1611
  • [23] PINCUS T, 1992, J RHEUMATOL, V19, P1885
  • [24] PINCUS T, 1993, RHEUM DIS CLIN N AM, V19, P123
  • [25] Proudman S. M., 1997, Arthritis and Rheumatism, V40, pS192
  • [26] Renal biopsy findings and followup of renal function in rheumatoid arthritis patients treated with cyclosporin A - An update from the International Kidney Biopsy Registry
    Rodriguez, F
    Krayenbuhl, JC
    Harrison, WB
    Forre, O
    Dijkmans, BAC
    Tugwell, P
    Miescher, PA
    Mihatsch, MJ
    [J]. ARTHRITIS AND RHEUMATISM, 1996, 39 (09): : 1491 - 1498
  • [27] Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases
    Salloum, E
    Cooper, DL
    Howe, G
    Lacy, J
    Tallini, G
    Crouch, J
    Schultz, M
    Murren, J
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (06) : 1943 - 1949
  • [28] METHOTREXATE - MECHANISM OF ACTION IN RHEUMATOID-ARTHRITIS
    SEGAL, R
    YARON, M
    TARTAKOVSKY, B
    [J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 1990, 20 (03) : 190 - 199
  • [29] Effect of combination therapy with cyclosporine and methotrexate on liver function test results in rheumatoid arthritis
    Stein, CM
    Brooks, RH
    Pincus, T
    [J]. ARTHRITIS AND RHEUMATISM, 1997, 40 (09): : 1721 - 1723
  • [30] Combination treatment of severe rheumatoid arthritis with cyclosporine and methotrexate for forty-eight weeks - An open-label extension study
    Stein, CM
    Pincus, T
    Yocum, D
    Tugwell, P
    Wells, G
    Gluck, O
    Kraag, G
    Torley, H
    Tesser, J
    McKendry, R
    Brooks, RH
    [J]. ARTHRITIS AND RHEUMATISM, 1997, 40 (10): : 1843 - 1851
1234