Combination treatment of rheumatoid arthritis with cyclosporine and methotrexate

被引：0
作者：
Stein, CM
Pincus, T
机构：
[1] Vanderbilt Univ, Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Med, Div Rheumatol, Nashville, TN 37232 USA
来源：
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 1999年 / 17卷 / 06期
关键词：
cyclosporine; methotrexate; combination therapy; rheumatoid arthritis;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In patients with rheumatoid arthritis (RA) not controlled on methotrexate (MTX) alone, clinical trials have shown that combination therapy with cyclosporine (CSA) and MTX is effective and relatively well tolerated over 12 months. Information regarding the long-term benefits, toxicities and tolerability of this combination therapy in clinical practice, and comparisons with alternative strategies, will determine the utility of the MTX plus CSA combination regimen in patients with RA not controlled with a single drug.
引用
收藏
页码：S47 / S52
页数：6
相关论文
共 38 条
  • [1] BENSEN W, 1994, J RHEUMATOL, V21, P2034
  • [2] Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis
    Boers, M
    Verhoeven, AC
    Markusse, HM
    vandeLaar, MAFJ
    Westhovens, R
    vanDenderen, JC
    vanZeben, D
    Dijkmans, BAC
    Peeters, AJ
    Jacobs, P
    vandenBrink, HR
    Schouten, HJA
    vanderHeijde, DMFM
    Boonen, A
    vanderLinden, S
    [J]. LANCET, 1997, 350 (9074) : 309 - 318
  • [3] SUPPRESSION OF COLLAGEN-INDUCED ARTHRITIS BY COMBINATION CYCLOSPORINE-A AND METHOTREXATE THERAPY
    BRAHN, E
    PEACOCK, DJ
    BANQUERIGO, ML
    [J]. ARTHRITIS AND RHEUMATISM, 1991, 34 (10): : 1282 - 1288
  • [4] LONG-TERM EFFICACY AND SAFETY OF CYCLOSPORINE IN RENAL-TRANSPLANT RECIPIENTS
    BURKE, JF
    PIRSCH, JD
    RAMOS, EL
    SALOMON, DR
    STABLEIN, DM
    VANBUREN, DH
    WEST, JC
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (06) : 358 - 363
  • [5] CASH JM, 1994, NEW ENGL J MED, V330, P1368
  • [6] Molecular therapeutics - Methotrexate and its mechanism of action
    Cronstein, BN
    [J]. ARTHRITIS AND RHEUMATISM, 1996, 39 (12): : 1951 - 1960
  • [7] DAWSON T, 1992, J RHEUMATOL, V19, P997
  • [8] AMERICAN-COLLEGE-OF-RHEUMATOLOGY PRELIMINARY DEFINITION OF IMPROVEMENT IN RHEUMATOID-ARTHRITIS
    FELSON, DT
    ANDERSON, JJ
    BOERS, M
    BOMBARDIER, C
    FURST, D
    GOLDSMITH, C
    KATZ, LM
    LIGHTFOOT, R
    PAULUS, H
    STRAND, V
    TUGWELL, P
    WEINBLATT, M
    WILLIAMS, HJ
    WOLFE, F
    KIESZAK, S
    [J]. ARTHRITIS AND RHEUMATISM, 1995, 38 (06): : 727 - 735
  • [9] THE EFFICACY AND TOXICITY OF COMBINATION THERAPY IN RHEUMATOID-ARTHRITIS - A METAANALYSIS
    FELSON, DT
    ANDERSON, JJ
    MEENAN, RF
    [J]. ARTHRITIS AND RHEUMATISM, 1994, 37 (10): : 1487 - 1491
  • [10] EPSTEIN-BARR VIRUS-ASSOCIATED HODGKINS LYMPHOMA IN A RHEUMATOID-ARTHRITIS PATIENT TREATED WITH METHOTREXATE AND CYCLOSPORINE-A
    FERRACCIOLI, GF
    CASATTA, L
    BARTOLI, E
    DEVITA, S
    DOLCETTI, R
    BOIOCCHI, M
    CARBONE, A
    [J]. ARTHRITIS AND RHEUMATISM, 1995, 38 (06): : 867 - 868
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