Bioactive Limonoids from the Leaves of Azaridachta indica (Neem)

被引：24

作者：

Gualtieri, Maria J. ^{[1
,2
]}

Malafronte, Nicola ^{[2
]}

Vassallo, Antonio ^{[3
]}

Braca, Alessandra ^{[4
]}

Cotugno, Roberta ^{[2
]}

Vasaturo, Michele ^{[2
]}

De Tommasi, Nunziatina ^{[2
]}

Dal Piaz, Fabrizio ^{[2
]}

机构：

[1] Univ Los Andes, Dept Farmacognosia & Med Organ, Lab Med Organ, Detras HULA,Sect Campo Oro, Merida 5101, Venezuela

[2] Univ Salerno, Dipartimento Farm, I-84084 Fisciano, SA, Italy

[3] Univ Basilicata, Dipartimento Sci, I-85100 Potenza, Italy

[4] Univ Pisa, Dipartimento Farm, I-56126 Pisa, Italy

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 03期

关键词：

AZADIRACHTA-INDICA; TETRACYCLIC TRITERPENOIDS; SIGNAL-TRANSDUCTION; HSP90; INHIBITOR; MELIA-AZEDARACH; TETRANORTRITERPENOIDS; DERIVATIVES; CANCER; 17-AAG; CELLS;

D O I：

10.1021/np400863d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1-9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated were assayed for their cytotoxicity against different cancer cell lines. Moreover, their ability to interact with the molecular chaperone Hsp90, affecting its biological activity, was tested.

引用

页码：596 / 602

页数：7

共 33 条

[1] Limonoids from the fruits of Melia azedarach and their cytotoxic activities
Akihisa, Toshihiro
Pan, Xin
Nakamura, Yasuhiro
Kikuchi, Takashi
Takahashi, Nami
Matsumoto, Masahiro
Ogihara, Eri
Fukatsu, Makoto
Koike, Kazuo
Tokuda, Harukuni
[J]. PHYTOCHEMISTRY, 2013, 89 : 59 - 70
[2] Melanogenesis Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids from the Seeds of Azadirachta indicia A. Juss. (Neem)
Akihisa, Toshihiro
Noto, Taisuke
Takahashi, Akitomo
Fujita, Yukiko
Banno, Norihiro
Tokuda, Harukuni
Koike, Kazuo
Suzuki, Takashi
Yasukawa, Ken
Kimura, Yumiko
[J]. JOURNAL OF OLEO SCIENCE, 2009, 58 (11) : 581 - 594
[3] A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity
Ansar, Sabah
Burlison, Joseph A.
Hadden, M. Kyle
Yu, Xiao Ming
Desino, Kelly E.
Bean, Jennifer
Neckers, Len
Audus, Ken L.
Michaelis, Mary L.
Blagg, Brian S. J.
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (07) : 1984 - 1990
[4] Insecticidal meliacarpins (C-seco limonoids) from Melia azedarach
Bohnenstengel, FI
Wray, V
Witte, L
Srivastava, RP
Proksch, P
[J]. PHYTOCHEMISTRY, 1999, 50 (06) : 977 - 982
[5] TETRANORTRITERPENOIDS RELATED TO NIMBIN AND NIMBOLIDE FROM AZADIRACHTA-INDICA JUSS,A. (MELIACEAE)
BOKEL, M
CRAMER, R
GUTZEIT, H
REEB, S
KRAUS, W
[J]. TETRAHEDRON, 1990, 46 (03) : 775 - 782
[6] Gedunin, a Novel Hsp90 inhibitor: Semisynthesis of Derivatives and Preliminary Structure-Activity Relationships
Brandt, Gary E. L.
Schmidt, Matthew D.
Prisinzano, Thomas E.
Blagg, Brian S. J.
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (20) : 6495 - 6502
[7] Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of hsp90 molecular chaperone
Clarke, PA
Hostein, I
Banerji, U
Di Stefano, F
Maloney, A
Walton, M
Judson, I
Workman, P
[J]. ONCOGENE, 2000, 19 (36) : 4125 - 4133
[8] Meliacin butenolides from Trichilia estipulata
Cortez, DAG
Fernandes, JB
Vieria, PC
Da Silva, MFGF
Ferreira, AG
Cass, QB
Pirani, JR
[J]. PHYTOCHEMISTRY, 1998, 49 (08) : 2493 - 2496
[9] A Chemical-Biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) Inhibitors
Dal Piaz, Fabrizio
Vassallo, Antonio
Temraz, Abeer
Cotugno, Roberta
Belisario, Maria A.
Bifulco, Giuseppe
Chini, Maria G.
Pisano, Claudio
De Tommasi, Nunziatina
Braca, Alessandra
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (04) : 1583 - 1595
[10] Natural Iminosugar (+)-Lentiginosine Inhibits ATPase and Chaperone Activity of Hsp90
Dal Piaz, Fabrizio
Vassallo, Antonio
Chini, Maria Giovanna
Cordero, Franca M.
Cardona, Francesca
Pisano, Claudio
Bifulco, Giuseppe
De Tommasi, Nunziatina
Brandi, Alberto
[J]. PLOS ONE, 2012, 7 (08):

← 1 2 3 4 →