How does your fat affect your liver when you drink?

被引：6

作者：

Hwang, Seonghwan ^{[1
]}

Gao, Bin ^{[1
]}

机构：

[1] NIAAA, Lab Liver Dis, NIH, 5625 Fishers Lane, Bethesda, MD 20892 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 06期

关键词：

BROWN ADIPOSE-TISSUE; OBESITY; THERMOGENESIS; DISEASE; IDENTIFICATION; INFLAMMATION; ALCOHOL;

D O I：

10.1172/JCI128984

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

White adipose tissue (WAT) dysfunction is generally thought to promote the development of alcoholic liver disease (ALD) in alcoholics by releasing free fatty acids and inflammatory mediators. This explains, at least in part, the synergistic or additive effects of alcohol and obesity on liver disease progression. In this issue of the JCI, Shen et al. establish a previously unrecognized concept that brain alcohol sensing enhances thermogenesis of brown adipose tissue (BAT) through sympathetic nerve activation. BAT functions as hepatoprotective machinery to counteract the development of ALD, implying a therapeutic potential of BAT activity modulation for the treatment of ALD.

引用

页码：2181 / 2183

页数：3

共 25 条

[1] Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease [J].

Betz, Matthias J. ;

Enerback, Sven .

NATURE REVIEWS ENDOCRINOLOGY, 2018, 14 (02) :77-87

[2] Chronic alcohol consumption decreases brown adipose tissue mass and disrupts thermoregulation: a possible role for altered retinoid signaling [J].

Blaner, William S. ;

Gao, Madeleine A. ;

Jiang, Hongfeng ;

Dalmer, Timothy R. A. ;

Hu, Xueyuan J. ;

Ginsberg, Henry N. ;

Clugston, Robin D. .

SCIENTIFIC REPORTS, 2017, 7

[3] Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes [J].

Bordicchia, Marica ;

Liu, Dianxin ;

Amri, Ez-Zoubir ;

Ailhaud, Gerard ;

Dessi-Fulgheri, Paolo ;

Zhang, Chaoying ;

Takahashi, Nobuyuki ;

Sarzani, Riccardo ;

Collins, Sheila .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (03) :1022-1036

[4] Identification and Importance of Brown Adipose Tissue in Adult Humans. [J].

Cypess, Aaron M. ;

Lehman, Sanaz ;

Williams, Gethin ;

Tal, Ilan ;

Rodman, Dean ;

Goldfine, Allison B. ;

Kuo, Frank C. ;

Palmer, Edwin L. ;

Tseng, Yu-Hua ;

Doria, Alessandro ;

Kolodny, Gerald M. ;

Kahn, C. Ronald .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (15) :1509-1517

[5] UCP1 Ablation Induces Obesity and Abolishes Diet-induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality [J].

Feldmann, Helena M. ;

Golozoubova, Valeria ;

Cannon, Barbara ;

Nedergaard, Jan .

CELL METABOLISM, 2009, 9 (02) :203-209

[6] SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy [J].

Feng, Daorong ;

Amgalan, Dulguun ;

Singh, Rajat ;

Wei, Jianwen ;

Wen, Jennifer ;

Wei, Tszki Peter ;

McGraw, Timothy E. ;

Kitsis, Richard N. ;

Pessin, Jeffrey E. .

JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (09) :3941-3956

[7] Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets [J].

Gao, Bin ;

Bataller, Ramon .

GASTROENTEROLOGY, 2011, 141 (05) :1572-1585

[8] Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C-C Motif) Receptor 2-Positive Macrophages and Lipolysis [J].

Kim, Seung-Jin ;

Feng, Dechun ;

Guillot, Adrien ;

Dai, Shen ;

Liu, Fengming ;

Hwang, Seonghwan ;

Parker, Richard ;

Seo, Wonhyo ;

He, Yong ;

Godlewski, Grzegorz ;

Jeong, Won-Il ;

Lin, Yuhong ;

Qin, Xuebin ;

Kunos, George ;

Gao, Bin .

HEPATOLOGY, 2019, 69 (05) :1965-1982

[9]

Lichtenbelt WDV, 2009, NEW ENGL J MED, V360, P1500, DOI 10.1056/NEJMoa0808718

[10] Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations [J].

Parker, Richard ;

Kim, Seung-Jin ;

Gao, Bin .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2018, 15 (01) :50-59

← 1 2 3 →