Effect of nicorandil upon different guinea-pig and rat isolated organ preparations in vitro

被引：0
|
作者：
Barcenilla, A
Alamo, C
Carvajal, A
García-Pozo, J
Velasco, A
机构：
[1] Univ Alcala de Henares, Dept Farmacol, Fac Med, E-28871 Alcala De Henares, Spain
[2] Univ Valladolid, Dept Pharmacol & Therapeut, Fac Med, Valladolid, Spain
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 2000年 / 50卷 / 04期
关键词：
CAS; 65141-46-0; guanylatecyclase activator; nicorandil; in vitro studies; rat; potassium channel activator;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A study of the effect of nicorandil (N-2-(hydroxyethyl)nicotinamide nitrate, CAS 65141-46-0), a potassium channel and guanylatecyclase activator, upon preparations of rat vas deferens and uterus, and guinea pig ileum was performed. Nicorandil does not modify rat isolated vas deferens responses to noradrenaline (norepinephrine) and potassium. The drug exerts a noncompetitive antagonist effect upon rat isolated uterus response to serotonin, histamine, oxytocin, and, at high concentrations, inhibits guinea-pig isolated ileum responses to acetylcholine, histamine, 4-aminopyridine and potassium.
引用
收藏
页码：E341 / E344
页数：4
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