Cryptococcal meningitis due to Cryptococcus neoformans genotype AFLP1/VNI in Iran: a review of the literature

被引：14

作者：

Badali, Hamid ^{[1
]}

Alian, Shahriar ^{[2
]}

Fakhim, Hamed ^{[3
]}

Falahatinejad, Mahsa ^{[3
]}

Moradi, Ali ^{[2
]}

Davoudi, Mehrnaz Mohammad ^{[3
]}

Hagen, Ferry ^{[4
]}

Meis, Jacques F. ^{[4
,5
]}

机构：

[1] Mazandaran Univ Med Sci, Dept Med Mycol & Parasitol, IFRC, Sari, Iran

[2] Mazandaran Univ Med Sci, Dept Infect Dis, ARRC, Sari, Iran

[3] Mazandaran Univ Med Sci, Student Res Comm, Sari, Iran

[4] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

[5] Radboudumc, Dept Med Microbiol, Nijmegen, Netherlands

来源：

MYCOSES | 2015年 / 58卷 / 12期

关键词：

Cryptococcus species; HIV; molecular identification; Iran; EPIDEMIOLOGIC CUTOFF VALUES; END-POINT DISTRIBUTIONS; GATTII SPECIES COMPLEX; AMPHOTERICIN-B; SUSCEPTIBILITY; PATIENT; FLUCONAZOLE; INFECTION;

D O I：

10.1111/myc.12415

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Cryptococcal meningitis is the most important opportunistic fungal infection with a high mortality in HIV-patients in less developed regions. Here, we report a case of cryptococcal meningitis in a 49-year-old HIV-positive female due to Cryptococcus neoformans (serotype A, mating-type alpha, genotype AFLP1/VNI) in Sari, Iran. In vitro antifungal susceptibility tests showed MICs of isavuconazole (0.016 g ml(-1)), voriconazole (0.031 g ml(-1)), posaconazole (0.031 g ml(-1)), itraconazole (0.063 g ml(-1)), amphotericin B (0.125 g ml(-1)) and fluconazole (8 g ml(-1)). Despite immediate antifungal therapy, the patient died 4 days later due to respiratory failure. Cryptococcal infections have been infrequently reported from Iran and therefore we analysed all published cases of cryptococcosis in Iran since the first reported case from 1969.

引用

页码：689 / 693

页数：5

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