Death, destruction, danger and dendritic cells

被引：20

作者：

Austyn, JM ^{[1
]}

机构：

[1] Royal Prince Alfred Hosp, Camperdown, NSW 2050, Australia

来源：

NATURE MEDICINE | 1999年 / 5卷 / 11期

关键词：

D O I：

10.1038/15182

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dendritic cells are known to be involved in recognition of foreign antigens and initiation of specific T-cell responses. The 'danger hypothesis' suggests that the immune system can also respond to endogenous signals of distress. New data indicate that dendritic cells are the first to respond to these signals, although the mechanisms involved in their activation are unclear (pages 1249–1255).

引用

页码：1232 / 1233

页数：2

共 10 条

[1] Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs [J].

Albert, ML ;

Sauter, B ;

Bhardwaj, N .

NATURE, 1998, 392 (6671) :86-89

[2]

Austyn J M, 1998, Curr Opin Hematol, V5, P3, DOI 10.1097/00062752-199801000-00002

[3] The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity [J].

Fazekas de St Groth, B .

IMMUNOLOGY TODAY, 1998, 19 (10) :448-454

[4] Natural adjuvants: Endogenous activators of dendritic cells [J].

Gallucci, S ;

Lolkema, M ;

Matzinger, P .

NATURE MEDICINE, 1999, 5 (11) :1249-1255

[5] Cross-tolerance: A pathway for inducing tolerance to peripheral tissue antigens [J].

Heath, WR ;

Kurts, C ;

Miller, JFAP ;

Carbone, FR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (10) :1549-1553

[6] Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells [J].

Inaba, K ;

Turley, S ;

Yamaide, F ;

Iyoda, T ;

Mahnke, K ;

Inaba, M ;

Pack, M ;

Subklewe, M ;

Sauter, B ;

Sheff, D ;

Albert, M ;

Bhardwaj, N ;

Mellman, I ;

Steinman, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (11) :2163-2173

[7]

JANEWAY CA, 1989, COLD SPRING HARB SYM, V54, P1

[8] TOLERANCE, DANGER, AND THE EXTENDED FAMILY [J].

MATZINGER, P .

ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 :991-1045

[9]

Rovere P, 1998, J IMMUNOL, V161, P4467

[10] The role of dendritic cells in the induction and regulation of immunity to microbial infection [J].

Sousa, CRE ;

Sher, A ;

Kaye, P .

CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (04) :392-399

← 1 →