Current and Future Targets for Mucosal Healing in Inflammatory Bowel Disease

被引：51

作者：

Atreya, Raja ^{[1
]}

Neurath, Markus F. ^{[1
]}

机构：

[1] Friedrich Alexander Univ Erlangen Nurnberg, Med Clin 1, Ulmenweg 18, D-91054 Erlangen, Germany

来源：

VISCERAL MEDICINE | 2017年 / 33卷 / 01期

关键词：

Mucosal healing; Inflammatory bowel diseases; Biologicals; Oligonucleotides; Small molecules; MODERATE ULCERATIVE-COLITIS; CROHNS-DISEASE; DOUBLE-BLIND; CLINICAL REMISSION; COMBINATION THERAPY; INDUCTION; MILD; INFLIXIMAB; PLACEBO; MESALAZINE;

D O I：

10.1159/000458006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The induction and subsequent maintenance of mucosal healing has emerged as one of the central therapeutic goals in the management of patients with inflammatory bowel disease (IBD) (Crohn's disease and ulcerative colitis). Current and novel treatment options are assessed regarding their therapeutic efficacy on the basis of their ability to induce mucosal healing. However, there is still substantial debate about the precise definition of mucosal healing. Here, we will give an overview regarding the definitions of mucosal healing as well as its probable effects on long-term disease behavior and finally focus on current and potential therapeutic targets to achieve this therapeutic goal in IBD patients. (C) 2017 S. Karger GmbH, Freiburg

引用

页码：82 / 88

页数：7

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