Morphological Evaluation of Wound Healing Events in the Excisional Wound Healing Model in Rats

被引：32

作者：

de Moura Estevao, Ligia Reis ^{[1
]}

Cassini-Vieira, Puebla ^{[2
]}

Borba Leite, Ana Greice ^{[1
]}

Vilar de Carvalho Bulhoes, Apolonia Agnes ^{[1
]}

Barcelos, Luciola da Silva ^{[3
]}

Evencio-Neto, Joaquim ^{[1
]}

机构：

[1] Univ Fed Rural Pernambuco UFRPE, Dept Morphol & Anim Physiol, Recife, PE, Brazil

[2] Rush Univ, Med Ctr, Canc Ctr, Dept Med,Div Hematol Oncol,Dept Immunol & Microbi, Chicago, IL 60612 USA

[3] Univ Fed Minas Gerais, Dept Physiol & Biophys ICB, Belo Horizonte, MG, Brazil

来源：

BIO-PROTOCOL | 2019年 / 9卷 / 13期

关键词：

Rat excisional wound; Histological score; Angiogenesis; Inflammation; Collagen deposition; Epithelialization;

D O I：

10.21769/BioProtoc.3285

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Skin wound healing is a complex process involving different events such as blood coagulation, inflammation, new blood vessels formation, and extracellular matrix deposition. These events can be observed by using histology techniques. However, the lack of the standardization of such parameters impacts on the reproducibility of results. Here, we describe a protocol to perform macroscopic and microscopic analyses of the events that occur during skin wound healing using the experimental model of excisional wounds in rats.

引用

页数：12

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