The genetic dissection of essential hypertension

被引:231
作者
Cowley, Allen W., Jr. [1 ]
机构
[1] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA
关键词
D O I
10.1038/nrg1967
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
QTL mapping in humans and rats has identified hundreds of blood-pressure-related phenotypes and genomic regions; the next daunting task is gene identification and validation. The development of novel rat model systems that mimic many elements of the human disease, coupled with advances in the genomic and informatic infrastructure for rats, promise to revolutionize the hunt for genes that determine susceptibility to hypertension. Furthermore, methods are evolving that should enable the identification of candidate genes in human populations. Together with the computational reconstruction of regulatory networks, these methods provide opportunities to significantly advance our understanding of the underlying aetiology of hypertension.
引用
收藏
页码:829 / 840
页数:12
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