An improved 62Zn/62Cu generator based on a cation exchanger and its fully remote-controlled preparation for clinical use

被引：31

作者：

Fukumura, Toshimitsu ^{[1
]}

Okada, Kazuhiro

Suzuki, Hisashi

Nakao, Ryuji

Mukai, Kensaku

Szelecsenyi, Ferenc

Kovacs, Zoltan

Suzuki, Kazutoshi

机构：

[1] Natl Inst Radiol Sci, Radiopharmaceut Chem Sect, Dept Med Imaging, Chiba 2638555, Japan

[2] Japan Steel Works, Ion Beam Grp, Muroran, Hokkaido 0518505, Japan

[3] Hungarian Acad Sci ATOMKI, Nucl Res Inst, Cyclotron Dept, H-4001 Debrecen, Hungary

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2006年 / 33卷 / 06期

基金：

匈牙利科学研究基金会; 日本学术振兴会;

关键词：

Zn-62/Cu-62; generator; weak acidic cation exchanger; Cu-62; automated dispensing system;

D O I：

10.1016/j.nucmedbio.2006.05.003

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Objective: The goal of this study was to develop an improved Zn-62/Cu-62 generator based on cation exchange resin and remote preparation at high radioactivity scale for clinical use. Methods: A natural Cu target was irradiated with proton beam in the energy range of 30 -> 19 MeV at a beam current of 10 mu A for I h to obtain around 1.7 GBq of Zn-62. The Zn-62 was isolated from the Cu target on an anion exchange column with more than 97% yield within 2.5 h from the EOB. The Zn-62/(CU)-C-62 generator was prepared by loading the Zn-62(2+) on a Sep-Pak plus CM cartridge. Results: The generator showed high elution efficiency (-96%) using a small volume (ca. 3 ml) of a 200-mM glycine solution with a very low breakthrough of Zn-62 (< 0.1%). Conclusions: This Zn-62/(CU)-C-62 generator has been proven to be highly useful as a source of Cu-62 for the synthesis of Cu-62-labeled compounds. The clinical application of [Cu-62] Cu-ATSM produced with this generator has been already approved by the Institutional Review Board at the National Institute of Radiological Sciences. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：821 / 827

页数：7

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